Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associated antigens and demonstrate its superiority to s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eugenia Zah, Eunwoo Nam, Vinya Bhuvan, Uyen Tran, Brenda Y. Ji, Stanley B. Gosliner, Xiuli Wang, Christine E. Brown, Yvonne Y. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec2f088f8b5544bbb62387a290932f01
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec2f088f8b5544bbb62387a290932f01
record_format	dspace
spelling	oai:doaj.org-article:ec2f088f8b5544bbb62387a290932f012021-12-02T14:42:48ZSystematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma10.1038/s41467-020-16160-52041-1723https://doaj.org/article/ec2f088f8b5544bbb62387a290932f012020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16160-5https://doaj.org/toc/2041-1723One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associated antigens and demonstrate its superiority to single-antigen CARs in a mouse model of MM.Eugenia ZahEunwoo NamVinya BhuvanUyen TranBrenda Y. JiStanley B. GoslinerXiuli WangChristine E. BrownYvonne Y. ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eugenia Zah Eunwoo Nam Vinya Bhuvan Uyen Tran Brenda Y. Ji Stanley B. Gosliner Xiuli Wang Christine E. Brown Yvonne Y. Chen Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma
description	One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associated antigens and demonstrate its superiority to single-antigen CARs in a mouse model of MM.
format	article
author	Eugenia Zah Eunwoo Nam Vinya Bhuvan Uyen Tran Brenda Y. Ji Stanley B. Gosliner Xiuli Wang Christine E. Brown Yvonne Y. Chen
author_facet	Eugenia Zah Eunwoo Nam Vinya Bhuvan Uyen Tran Brenda Y. Ji Stanley B. Gosliner Xiuli Wang Christine E. Brown Yvonne Y. Chen
author_sort	Eugenia Zah
title	Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma
title_short	Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma
title_full	Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma
title_fullStr	Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma
title_full_unstemmed	Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma
title_sort	systematically optimized bcma/cs1 bispecific car-t cells robustly control heterogeneous multiple myeloma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ec2f088f8b5544bbb62387a290932f01
work_keys_str_mv	AT eugeniazah systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT eunwoonam systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT vinyabhuvan systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT uyentran systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT brendayji systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT stanleybgosliner systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT xiuliwang systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT christineebrown systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma AT yvonneychen systematicallyoptimizedbcmacs1bispecificcartcellsrobustlycontrolheterogeneousmultiplemyeloma
_version_	1718389603794157568

Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Ejemplares similares