Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.

Nucleotide-binding domain leucine-rich repeat (NLR) protein complexes sense infections and trigger robust immune responses in plants and humans. Activation of plant NLR resistance (R) proteins by pathogen effectors launches convergent immune responses, including programmed cell death (PCD), reactive...

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Autores principales:	Xiquan Gao, Xin Chen, Wenwei Lin, Sixue Chen, Dongping Lu, Yajie Niu, Lei Li, Cheng Cheng, Matthew McCormack, Jen Sheen, Libo Shan, Ping He
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ec2f5fd5b7c94a53941764ac59aecda4
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spelling	oai:doaj.org-article:ec2f5fd5b7c94a53941764ac59aecda42021-11-18T06:06:07ZBifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.1553-73661553-737410.1371/journal.ppat.1003127https://doaj.org/article/ec2f5fd5b7c94a53941764ac59aecda42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382673/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Nucleotide-binding domain leucine-rich repeat (NLR) protein complexes sense infections and trigger robust immune responses in plants and humans. Activation of plant NLR resistance (R) proteins by pathogen effectors launches convergent immune responses, including programmed cell death (PCD), reactive oxygen species (ROS) production and transcriptional reprogramming with elusive mechanisms. Functional genomic and biochemical genetic screens identified six closely related Arabidopsis Ca²⁺-dependent protein kinases (CPKs) in mediating bifurcate immune responses activated by NLR proteins, RPS2 and RPM1. The dynamics of differential CPK1/2 activation by pathogen effectors controls the onset of cell death. Sustained CPK4/5/6/11 activation directly phosphorylates a specific subgroup of WRKY transcription factors, WRKY8/28/48, to synergistically regulate transcriptional reprogramming crucial for NLR-dependent restriction of pathogen growth, whereas CPK1/2/4/11 phosphorylate plasma membrane-resident NADPH oxidases for ROS production. Our studies delineate bifurcation of complex signaling mechanisms downstream of NLR immune sensors mediated by the myriad action of CPKs with distinct substrate specificity and subcellular dynamics.Xiquan GaoXin ChenWenwei LinSixue ChenDongping LuYajie NiuLei LiCheng ChengMatthew McCormackJen SheenLibo ShanPing HePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 1, p e1003127 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Xiquan Gao Xin Chen Wenwei Lin Sixue Chen Dongping Lu Yajie Niu Lei Li Cheng Cheng Matthew McCormack Jen Sheen Libo Shan Ping He Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.
description	Nucleotide-binding domain leucine-rich repeat (NLR) protein complexes sense infections and trigger robust immune responses in plants and humans. Activation of plant NLR resistance (R) proteins by pathogen effectors launches convergent immune responses, including programmed cell death (PCD), reactive oxygen species (ROS) production and transcriptional reprogramming with elusive mechanisms. Functional genomic and biochemical genetic screens identified six closely related Arabidopsis Ca²⁺-dependent protein kinases (CPKs) in mediating bifurcate immune responses activated by NLR proteins, RPS2 and RPM1. The dynamics of differential CPK1/2 activation by pathogen effectors controls the onset of cell death. Sustained CPK4/5/6/11 activation directly phosphorylates a specific subgroup of WRKY transcription factors, WRKY8/28/48, to synergistically regulate transcriptional reprogramming crucial for NLR-dependent restriction of pathogen growth, whereas CPK1/2/4/11 phosphorylate plasma membrane-resident NADPH oxidases for ROS production. Our studies delineate bifurcation of complex signaling mechanisms downstream of NLR immune sensors mediated by the myriad action of CPKs with distinct substrate specificity and subcellular dynamics.
format	article
author	Xiquan Gao Xin Chen Wenwei Lin Sixue Chen Dongping Lu Yajie Niu Lei Li Cheng Cheng Matthew McCormack Jen Sheen Libo Shan Ping He
author_facet	Xiquan Gao Xin Chen Wenwei Lin Sixue Chen Dongping Lu Yajie Niu Lei Li Cheng Cheng Matthew McCormack Jen Sheen Libo Shan Ping He
author_sort	Xiquan Gao
title	Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.
title_short	Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.
title_full	Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.
title_fullStr	Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.
title_full_unstemmed	Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.
title_sort	bifurcation of arabidopsis nlr immune signaling via ca²⁺-dependent protein kinases.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ec2f5fd5b7c94a53941764ac59aecda4
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Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.

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