Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells

Measuring metabolic fluxes in cellular compartments is a challenge. Here, the authors introduce an approach to infer fluxes in mitochondria and cytosol, and find that IDH1 is the major producer of cytosolic citrate in HeLa cells and that in SDH- deficient cells citrate synthase functions in reverse.

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Autores principales:	Won Dong Lee, Dzmitry Mukha, Elina Aizenshtein, Tomer Shlomi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec32e3d593c84f86801f75a12d35a23c
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spelling	oai:doaj.org-article:ec32e3d593c84f86801f75a12d35a23c2021-12-02T14:39:19ZSpatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells10.1038/s41467-019-09352-12041-1723https://doaj.org/article/ec32e3d593c84f86801f75a12d35a23c2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09352-1https://doaj.org/toc/2041-1723Measuring metabolic fluxes in cellular compartments is a challenge. Here, the authors introduce an approach to infer fluxes in mitochondria and cytosol, and find that IDH1 is the major producer of cytosolic citrate in HeLa cells and that in SDH- deficient cells citrate synthase functions in reverse.Won Dong LeeDzmitry MukhaElina AizenshteinTomer ShlomiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Won Dong Lee Dzmitry Mukha Elina Aizenshtein Tomer Shlomi Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
description	Measuring metabolic fluxes in cellular compartments is a challenge. Here, the authors introduce an approach to infer fluxes in mitochondria and cytosol, and find that IDH1 is the major producer of cytosolic citrate in HeLa cells and that in SDH- deficient cells citrate synthase functions in reverse.
format	article
author	Won Dong Lee Dzmitry Mukha Elina Aizenshtein Tomer Shlomi
author_facet	Won Dong Lee Dzmitry Mukha Elina Aizenshtein Tomer Shlomi
author_sort	Won Dong Lee
title	Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
title_short	Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
title_full	Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
title_fullStr	Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
title_full_unstemmed	Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
title_sort	spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ec32e3d593c84f86801f75a12d35a23c
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Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells

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