Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review

Background and purpose: Several traditional risk factors of atherosclerosis such as age, obesity, and altered lipid metabolism are shared with osteoarthritis (OA). Metabolic abnormalities and atheromatous vascular disease are linked with systemic inflammation and progression of OA. Hence, treatment...

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Autores principales:	Behzad Heidari, Mansour Babaei, Behnaz Yosefghahri
Formato:	article
Lenguaje:	EN
Publicado:	PCO Convin S.A. 2021
Materias:	osteoarthritis statin therapy symptom incidence progression Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/ec3430a233b54f66ac0b14b8b4d0eab2
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spelling	oai:doaj.org-article:ec3430a233b54f66ac0b14b8b4d0eab22021-11-08T08:28:47ZPrevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review2529-198X10.31138/mjr.32.3.227https://doaj.org/article/ec3430a233b54f66ac0b14b8b4d0eab22021-01-01T00:00:00Zhttp://www.mjrheum.org/assets/files/792/file330_1354.pdfhttps://doaj.org/toc/2529-198XBackground and purpose: Several traditional risk factors of atherosclerosis such as age, obesity, and altered lipid metabolism are shared with osteoarthritis (OA). Metabolic abnormalities and atheromatous vascular disease are linked with systemic inflammation and progression of OA. Hence, treatment of OA with statins is expected to improve metabolic abnormalities and prevent OA progression. Many studies which have addressed this issue found inconsistent results. This review aims to elucidate the effect of statins in OA by summarizing the existing data. Methods: Potential studies in English language published in Medline/PubMed, Scopus and Google Scholar since 2000 were searched by using keywords such as osteoarthritis, statins, progression, treatment, prevalence, synovitis, pain. Fourteen papers were found to be relevant and were summarised. Results: Data regarding symptomatic effect of statins in OA are scarce and the results varied from no effect to a small improvement or even increased risk of pain in knee OA. However, most studies on the incidence and progression of OA found a significant decreased risk of incident OA, as well as reduced risk of radiographic progression in statin users vs. non-users. Factors such as patient adherence, duration of treatment, and higher cumulative statin doses were associated with greater efficacy. Conclusion: Existing data indicate a preventing effect of statin therapy on OA progression. However, unless a formal meta-analysis with weight analysis is made, a conclusion cannot be drawn.Behzad HeidariMansour BabaeiBehnaz YosefghahriPCO Convin S.A.articleosteoarthritisstatin therapysymptomincidenceprogressionDiseases of the musculoskeletal systemRC925-935ENMediterranean Journal of Rheumatology, Vol 32, Iss 3, Pp 227-236 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis statin therapy symptom incidence progression Diseases of the musculoskeletal system RC925-935
spellingShingle	osteoarthritis statin therapy symptom incidence progression Diseases of the musculoskeletal system RC925-935 Behzad Heidari Mansour Babaei Behnaz Yosefghahri Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
description	Background and purpose: Several traditional risk factors of atherosclerosis such as age, obesity, and altered lipid metabolism are shared with osteoarthritis (OA). Metabolic abnormalities and atheromatous vascular disease are linked with systemic inflammation and progression of OA. Hence, treatment of OA with statins is expected to improve metabolic abnormalities and prevent OA progression. Many studies which have addressed this issue found inconsistent results. This review aims to elucidate the effect of statins in OA by summarizing the existing data. Methods: Potential studies in English language published in Medline/PubMed, Scopus and Google Scholar since 2000 were searched by using keywords such as osteoarthritis, statins, progression, treatment, prevalence, synovitis, pain. Fourteen papers were found to be relevant and were summarised. Results: Data regarding symptomatic effect of statins in OA are scarce and the results varied from no effect to a small improvement or even increased risk of pain in knee OA. However, most studies on the incidence and progression of OA found a significant decreased risk of incident OA, as well as reduced risk of radiographic progression in statin users vs. non-users. Factors such as patient adherence, duration of treatment, and higher cumulative statin doses were associated with greater efficacy. Conclusion: Existing data indicate a preventing effect of statin therapy on OA progression. However, unless a formal meta-analysis with weight analysis is made, a conclusion cannot be drawn.
format	article
author	Behzad Heidari Mansour Babaei Behnaz Yosefghahri
author_facet	Behzad Heidari Mansour Babaei Behnaz Yosefghahri
author_sort	Behzad Heidari
title	Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
title_short	Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
title_full	Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
title_fullStr	Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
title_full_unstemmed	Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review
title_sort	prevention of osteoarthritis progression by statins, targeting metabolic and inflammatory aspects: a review
publisher	PCO Convin S.A.
publishDate	2021
url	https://doaj.org/article/ec3430a233b54f66ac0b14b8b4d0eab2
work_keys_str_mv	AT behzadheidari preventionofosteoarthritisprogressionbystatinstargetingmetabolicandinflammatoryaspectsareview AT mansourbabaei preventionofosteoarthritisprogressionbystatinstargetingmetabolicandinflammatoryaspectsareview AT behnazyosefghahri preventionofosteoarthritisprogressionbystatinstargetingmetabolicandinflammatoryaspectsareview
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Prevention of Osteoarthritis Progression by Statins, Targeting Metabolic and Inflammatory Aspects: A Review

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