CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Jeffery et al. develop a system of inducible and reversible CENP-A overexpression, combined with a switch in p53 status in human cell lines. They find the tumor suppressor p53 as a key determinant of how CENP-A impacts cell state, cell identity and therapeutic response. This study suggests that CENP...

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Autores principales:	Daniel Jeffery, Alberto Gatto, Katrina Podsypanina, Charlène Renaud-Pageot, Rebeca Ponce Landete, Lorraine Bonneville, Marie Dumont, Daniele Fachinetti, Geneviève Almouzni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ec3aeda702904a2b82c7ea6a96ce10f4
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spelling	oai:doaj.org-article:ec3aeda702904a2b82c7ea6a96ce10f42021-12-02T16:36:02ZCENP-A overexpression promotes distinct fates in human cells, depending on p53 status10.1038/s42003-021-01941-52399-3642https://doaj.org/article/ec3aeda702904a2b82c7ea6a96ce10f42021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01941-5https://doaj.org/toc/2399-3642Jeffery et al. develop a system of inducible and reversible CENP-A overexpression, combined with a switch in p53 status in human cell lines. They find the tumor suppressor p53 as a key determinant of how CENP-A impacts cell state, cell identity and therapeutic response. This study suggests that CENP-A overexpression promotes the reprogramming of cell fates in the context of tumor evolution.Daniel JefferyAlberto GattoKatrina PodsypaninaCharlène Renaud-PageotRebeca Ponce LandeteLorraine BonnevilleMarie DumontDaniele FachinettiGeneviève AlmouzniNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Daniel Jeffery Alberto Gatto Katrina Podsypanina Charlène Renaud-Pageot Rebeca Ponce Landete Lorraine Bonneville Marie Dumont Daniele Fachinetti Geneviève Almouzni CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
description	Jeffery et al. develop a system of inducible and reversible CENP-A overexpression, combined with a switch in p53 status in human cell lines. They find the tumor suppressor p53 as a key determinant of how CENP-A impacts cell state, cell identity and therapeutic response. This study suggests that CENP-A overexpression promotes the reprogramming of cell fates in the context of tumor evolution.
format	article
author	Daniel Jeffery Alberto Gatto Katrina Podsypanina Charlène Renaud-Pageot Rebeca Ponce Landete Lorraine Bonneville Marie Dumont Daniele Fachinetti Geneviève Almouzni
author_facet	Daniel Jeffery Alberto Gatto Katrina Podsypanina Charlène Renaud-Pageot Rebeca Ponce Landete Lorraine Bonneville Marie Dumont Daniele Fachinetti Geneviève Almouzni
author_sort	Daniel Jeffery
title	CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
title_short	CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
title_full	CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
title_fullStr	CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
title_full_unstemmed	CENP-A overexpression promotes distinct fates in human cells, depending on p53 status
title_sort	cenp-a overexpression promotes distinct fates in human cells, depending on p53 status
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec3aeda702904a2b82c7ea6a96ce10f4
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CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

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