Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy

Mansing Ratanasukon, Koblarp Thongthong, Patama Bhurayanontachai, Pichai JirarattanasopaDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat yai, Songkhla Province, ThailandBackground: To evaluate photoreceptor disruption in patients with central serous chorioretinopat...

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Autores principales:	Ratanasukon M, Thongthong K, Bhurayanontachai P, Jirarattanasopa P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ec3b1c3cfe3c4fdd8d2340eb9d5cffd1
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spelling	oai:doaj.org-article:ec3b1c3cfe3c4fdd8d2340eb9d5cffd12021-12-02T06:35:35ZPhotoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy1177-54671177-5483https://doaj.org/article/ec3b1c3cfe3c4fdd8d2340eb9d5cffd12013-01-01T00:00:00Zhttp://www.dovepress.com/photoreceptor-disruption-in-central-serous-chorioretinopathy-treated-b-a11927https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Mansing Ratanasukon, Koblarp Thongthong, Patama Bhurayanontachai, Pichai JirarattanasopaDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat yai, Songkhla Province, ThailandBackground: To evaluate photoreceptor disruption in patients with central serous chorioretinopathy (CSC) treated by half-dose photodynamic therapy (PDT).Methods: A total of 29 patients with symptomatic CSC were recruited and underwent half-dose verteporfin PDT covering the leakage sites as observed via fundus fluorescein angiography. The primary outcome was the percentage of patients with the presence of photoreceptor disruption, and the secondary outcome was the correlation between photoreceptor disruption and visual results at the 1-year follow-up.Results: Photoreceptor disruption was identified in 13 eyes (44.8%) 12 months after treatment. Twenty-seven patients experienced best-corrected visual acuity (BCVA) improvement after PDT, while two patients showed stable BCVA. The mean BCVA in patients with photoreceptor disruption at the baseline and every follow-up visit was significantly lower than that of patients without photoreceptor disruption. However, there was no correlation between the presence or absence of photoreceptor disruption and the improvement of visual acuity because the BCVA gain at the last follow-up visit between the two groups was not significant (P = 0.69). No potential ocular complication was encountered in the study.Conclusion: Photoreceptor disruption was found in about 45% of CSC patients treated by PDT, which ultimately resulted in poor visual outcomes. However, a half-dose PDT might not affect or modify the photoreceptor function because it gave the same pattern of visual recovery in patients with and without photoreceptor cell loss.Keywords: photoreceptor disruption, central serous chorioretinopathy, photodynamic therapyRatanasukon MThongthong KBhurayanontachai PJirarattanasopa PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 87-92 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ratanasukon M Thongthong K Bhurayanontachai P Jirarattanasopa P Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
description	Mansing Ratanasukon, Koblarp Thongthong, Patama Bhurayanontachai, Pichai JirarattanasopaDepartment of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat yai, Songkhla Province, ThailandBackground: To evaluate photoreceptor disruption in patients with central serous chorioretinopathy (CSC) treated by half-dose photodynamic therapy (PDT).Methods: A total of 29 patients with symptomatic CSC were recruited and underwent half-dose verteporfin PDT covering the leakage sites as observed via fundus fluorescein angiography. The primary outcome was the percentage of patients with the presence of photoreceptor disruption, and the secondary outcome was the correlation between photoreceptor disruption and visual results at the 1-year follow-up.Results: Photoreceptor disruption was identified in 13 eyes (44.8%) 12 months after treatment. Twenty-seven patients experienced best-corrected visual acuity (BCVA) improvement after PDT, while two patients showed stable BCVA. The mean BCVA in patients with photoreceptor disruption at the baseline and every follow-up visit was significantly lower than that of patients without photoreceptor disruption. However, there was no correlation between the presence or absence of photoreceptor disruption and the improvement of visual acuity because the BCVA gain at the last follow-up visit between the two groups was not significant (P = 0.69). No potential ocular complication was encountered in the study.Conclusion: Photoreceptor disruption was found in about 45% of CSC patients treated by PDT, which ultimately resulted in poor visual outcomes. However, a half-dose PDT might not affect or modify the photoreceptor function because it gave the same pattern of visual recovery in patients with and without photoreceptor cell loss.Keywords: photoreceptor disruption, central serous chorioretinopathy, photodynamic therapy
format	article
author	Ratanasukon M Thongthong K Bhurayanontachai P Jirarattanasopa P
author_facet	Ratanasukon M Thongthong K Bhurayanontachai P Jirarattanasopa P
author_sort	Ratanasukon M
title	Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
title_short	Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
title_full	Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
title_fullStr	Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
title_full_unstemmed	Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
title_sort	photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ec3b1c3cfe3c4fdd8d2340eb9d5cffd1
work_keys_str_mv	AT ratanasukonm photoreceptordisruptionincentralserouschorioretinopathytreatedbyhalfdosephotodynamictherapy AT thongthongk photoreceptordisruptionincentralserouschorioretinopathytreatedbyhalfdosephotodynamictherapy AT bhurayanontachaip photoreceptordisruptionincentralserouschorioretinopathytreatedbyhalfdosephotodynamictherapy AT jirarattanasopap photoreceptordisruptionincentralserouschorioretinopathytreatedbyhalfdosephotodynamictherapy
_version_	1718399846325420032

Photoreceptor disruption in central serous chorioretinopathy treated by half-dose photodynamic therapy

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