Changing epidemiology of dengue in Sri Lanka-Challenges for the future.

<h4>Background</h4>Dengue infections are on the rise in Sri Lanka and are spreading to all areas in the country. Here, we discuss the changes in dengue epidemiology in Sri Lanka in relation to changes in age distribution, changes in seroprevalence rates over time, and possible reasons co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gathsaurie Neelika Malavige, Chandima Jeewandara, Azhar Ghouse, Gayasha Somathilake, Hasitha Tissera
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ec3d3b2234e345b6b3f6ae2547c61e2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec3d3b2234e345b6b3f6ae2547c61e2e
record_format	dspace
spelling	oai:doaj.org-article:ec3d3b2234e345b6b3f6ae2547c61e2e2021-12-02T20:23:37ZChanging epidemiology of dengue in Sri Lanka-Challenges for the future.1935-27271935-273510.1371/journal.pntd.0009624https://doaj.org/article/ec3d3b2234e345b6b3f6ae2547c61e2e2021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009624https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Dengue infections are on the rise in Sri Lanka and are spreading to all areas in the country. Here, we discuss the changes in dengue epidemiology in Sri Lanka in relation to changes in age distribution, changes in seroprevalence rates over time, and possible reasons contributing to such changes.<h4>Methods and findings</h4>Although the incidence of dengue increased 20-fold from the year 2000 to 2012 and a further 3-fold from 2012 to 2019, this increase is not reflected in a similar increase in the age-stratified seropositivity rates for dengue. For instance, the annual seroconversion rates were 0.76% in 2013 and 0.91% in 2017. The annual seroconversion rates in the 6 to 17 age group were 1.5% per year in 2003, 3.9% in 2013, and 4.1% in 2017. In addition, although a 13-fold increase in dengue was seen in those who were <19 years of age, a 52.4-fold increase was seen in the 40- to 59-year age group. The case fatality rates (CFRs) have similarly changed, with 61.8% of deaths occurring in those <19 years of age in the year 2000, while in 2012 to 2018, the highest CFR were seen in those who were aged 20 to 39 years. Although there has been a marked increase in the number of cases, the vector densities did not change during a 4-year period. The proportion of adult individuals experiencing a secondary dengue infection has also remained between 65% and 75% between the years 2004 and 2018.<h4>Conclusions</h4>A change in the ratio of symptomatic to asymptomatic infections can give rise to changes in the reported incidence of dengue. In order to take an appropriate policy decision in dengue control activities, it would be important to study the changes in virus serotypes, vector dispersion, and densities. Further, the contribution of the rise in metabolic diseases to an increase in the symptomatic as well as more severe infections due to dengue is explored.Gathsaurie Neelika MalavigeChandima JeewandaraAzhar GhouseGayasha SomathilakeHasitha TisseraPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009624 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Gathsaurie Neelika Malavige Chandima Jeewandara Azhar Ghouse Gayasha Somathilake Hasitha Tissera Changing epidemiology of dengue in Sri Lanka-Challenges for the future.
description	<h4>Background</h4>Dengue infections are on the rise in Sri Lanka and are spreading to all areas in the country. Here, we discuss the changes in dengue epidemiology in Sri Lanka in relation to changes in age distribution, changes in seroprevalence rates over time, and possible reasons contributing to such changes.<h4>Methods and findings</h4>Although the incidence of dengue increased 20-fold from the year 2000 to 2012 and a further 3-fold from 2012 to 2019, this increase is not reflected in a similar increase in the age-stratified seropositivity rates for dengue. For instance, the annual seroconversion rates were 0.76% in 2013 and 0.91% in 2017. The annual seroconversion rates in the 6 to 17 age group were 1.5% per year in 2003, 3.9% in 2013, and 4.1% in 2017. In addition, although a 13-fold increase in dengue was seen in those who were <19 years of age, a 52.4-fold increase was seen in the 40- to 59-year age group. The case fatality rates (CFRs) have similarly changed, with 61.8% of deaths occurring in those <19 years of age in the year 2000, while in 2012 to 2018, the highest CFR were seen in those who were aged 20 to 39 years. Although there has been a marked increase in the number of cases, the vector densities did not change during a 4-year period. The proportion of adult individuals experiencing a secondary dengue infection has also remained between 65% and 75% between the years 2004 and 2018.<h4>Conclusions</h4>A change in the ratio of symptomatic to asymptomatic infections can give rise to changes in the reported incidence of dengue. In order to take an appropriate policy decision in dengue control activities, it would be important to study the changes in virus serotypes, vector dispersion, and densities. Further, the contribution of the rise in metabolic diseases to an increase in the symptomatic as well as more severe infections due to dengue is explored.
format	article
author	Gathsaurie Neelika Malavige Chandima Jeewandara Azhar Ghouse Gayasha Somathilake Hasitha Tissera
author_facet	Gathsaurie Neelika Malavige Chandima Jeewandara Azhar Ghouse Gayasha Somathilake Hasitha Tissera
author_sort	Gathsaurie Neelika Malavige
title	Changing epidemiology of dengue in Sri Lanka-Challenges for the future.
title_short	Changing epidemiology of dengue in Sri Lanka-Challenges for the future.
title_full	Changing epidemiology of dengue in Sri Lanka-Challenges for the future.
title_fullStr	Changing epidemiology of dengue in Sri Lanka-Challenges for the future.
title_full_unstemmed	Changing epidemiology of dengue in Sri Lanka-Challenges for the future.
title_sort	changing epidemiology of dengue in sri lanka-challenges for the future.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ec3d3b2234e345b6b3f6ae2547c61e2e
work_keys_str_mv	AT gathsaurieneelikamalavige changingepidemiologyofdengueinsrilankachallengesforthefuture AT chandimajeewandara changingepidemiologyofdengueinsrilankachallengesforthefuture AT azharghouse changingepidemiologyofdengueinsrilankachallengesforthefuture AT gayashasomathilake changingepidemiologyofdengueinsrilankachallengesforthefuture AT hasithatissera changingepidemiologyofdengueinsrilankachallengesforthefuture
_version_	1718374140449128448

Changing epidemiology of dengue in Sri Lanka-Challenges for the future.

Ejemplares similares