In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by reducing secretion of muscle stem cell quiescence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chao Wang, Ruben Rabadan Ros, Paloma Martinez-Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Pedro Guillen-Garcia, Pradeep Reddy, Juan Carlos Izpisua Belmonte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec46029f8e914da49e6eeddd4f0bc4ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec46029f8e914da49e6eeddd4f0bc4ed
record_format	dspace
spelling	oai:doaj.org-article:ec46029f8e914da49e6eeddd4f0bc4ed2021-12-02T15:49:27ZIn vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche10.1038/s41467-021-23353-z2041-1723https://doaj.org/article/ec46029f8e914da49e6eeddd4f0bc4ed2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23353-zhttps://doaj.org/toc/2041-1723Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by reducing secretion of muscle stem cell quiescence promoting Wnt4.Chao WangRuben Rabadan RosPaloma Martinez-RedondoZaijun MaLei ShiYuan XueIsabel Guillen-GuillenLing HuangTomoaki HishidaHsin-Kai LiaoEstrella Nuñez DelicadoConcepcion Rodriguez EstebanPedro Guillen-GarciaPradeep ReddyJuan Carlos Izpisua BelmonteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Wang Ruben Rabadan Ros Paloma Martinez-Redondo Zaijun Ma Lei Shi Yuan Xue Isabel Guillen-Guillen Ling Huang Tomoaki Hishida Hsin-Kai Liao Estrella Nuñez Delicado Concepcion Rodriguez Esteban Pedro Guillen-Garcia Pradeep Reddy Juan Carlos Izpisua Belmonte In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
description	Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by reducing secretion of muscle stem cell quiescence promoting Wnt4.
format	article
author	Chao Wang Ruben Rabadan Ros Paloma Martinez-Redondo Zaijun Ma Lei Shi Yuan Xue Isabel Guillen-Guillen Ling Huang Tomoaki Hishida Hsin-Kai Liao Estrella Nuñez Delicado Concepcion Rodriguez Esteban Pedro Guillen-Garcia Pradeep Reddy Juan Carlos Izpisua Belmonte
author_facet	Chao Wang Ruben Rabadan Ros Paloma Martinez-Redondo Zaijun Ma Lei Shi Yuan Xue Isabel Guillen-Guillen Ling Huang Tomoaki Hishida Hsin-Kai Liao Estrella Nuñez Delicado Concepcion Rodriguez Esteban Pedro Guillen-Garcia Pradeep Reddy Juan Carlos Izpisua Belmonte
author_sort	Chao Wang
title	In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
title_short	In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
title_full	In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
title_fullStr	In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
title_full_unstemmed	In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
title_sort	in vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec46029f8e914da49e6eeddd4f0bc4ed
work_keys_str_mv	AT chaowang invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT rubenrabadanros invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT palomamartinezredondo invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT zaijunma invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT leishi invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT yuanxue invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT isabelguillenguillen invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT linghuang invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT tomoakihishida invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT hsinkailiao invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT estrellanunezdelicado invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT concepcionrodriguezesteban invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT pedroguillengarcia invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT pradeepreddy invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche AT juancarlosizpisuabelmonte invivopartialreprogrammingofmyofiberspromotesmuscleregenerationbyremodelingthestemcellniche
_version_	1718385724985704448

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Ejemplares similares