Primary prevention of venous thromboembolism in elderly medical patients

Karine Lacut, Grégoire Le Gal, Dominique MottierGETBO EA 3878, CHU de Brest, Department of Internal Medicine and Chest Diseases, Hôpital Cavale Blanche, Brest, FranceAbstract: Primary prophylaxis with the use of an effective and safe intervention appears the best approach of ven...

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Autores principales:	Karine Lacut, Grégoire Le Gal, Dominique Mottier
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ec4a73c3bce841038a92d70d493da04a
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spelling	oai:doaj.org-article:ec4a73c3bce841038a92d70d493da04a2021-12-02T00:52:01ZPrimary prevention of venous thromboembolism in elderly medical patients1178-1998https://doaj.org/article/ec4a73c3bce841038a92d70d493da04a2008-09-01T00:00:00Zhttps://www.dovepress.com/primary-prevention-of-venous-thromboembolism-in-elderly-medical-patien-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Karine Lacut, Grégoire Le Gal, Dominique MottierGETBO EA 3878, CHU de Brest, Department of Internal Medicine and Chest Diseases, Hôpital Cavale Blanche, Brest, FranceAbstract: Primary prophylaxis with the use of an effective and safe intervention appears the best approach of venous thromboembolism (VTE) management in medical elderly patients, the most affected by VTE. With increasing life expectancy, prevention of VTE, particularly in elderly patients, will arise as a major public health problem. Few well designed clinical trials evaluating thromboprophylaxis in medical settings were conducted in the specific population of geriatric patients. However, among the several pharmacological treatments evaluated, low molecular weight heparins enoxaparin 40 mg daily or dalteparin 5000 IU daily appeared effective and safe in the prevention of VTE in elderly patients. Despite available data, and recommendations for VTE prevention in medical patients, thromboprophylaxis is underused or misused in practice. Heterogeneity of clinical studies, selected populations, concern about bleeding, and lack of a clear clinical benefit are some of the reasons that could explain the gap between theory and practice. In this review, after a brief report of epidemiologic data and specificities of VTE in elderly patients, the authors discuss the available results of VTE primary prevention trials for elderly medical patients, the limitations of these data, and the challenges to improve the practice and to reduce the incidence of this frequent but preventable disease.Keywords: venous thromboembolism, prophylaxis, elderly patients, medical settings, reviewKarine LacutGrégoire Le GalDominique MottierDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 399-411 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Karine Lacut Grégoire Le Gal Dominique Mottier Primary prevention of venous thromboembolism in elderly medical patients
description	Karine Lacut, Grégoire Le Gal, Dominique MottierGETBO EA 3878, CHU de Brest, Department of Internal Medicine and Chest Diseases, Hôpital Cavale Blanche, Brest, FranceAbstract: Primary prophylaxis with the use of an effective and safe intervention appears the best approach of venous thromboembolism (VTE) management in medical elderly patients, the most affected by VTE. With increasing life expectancy, prevention of VTE, particularly in elderly patients, will arise as a major public health problem. Few well designed clinical trials evaluating thromboprophylaxis in medical settings were conducted in the specific population of geriatric patients. However, among the several pharmacological treatments evaluated, low molecular weight heparins enoxaparin 40 mg daily or dalteparin 5000 IU daily appeared effective and safe in the prevention of VTE in elderly patients. Despite available data, and recommendations for VTE prevention in medical patients, thromboprophylaxis is underused or misused in practice. Heterogeneity of clinical studies, selected populations, concern about bleeding, and lack of a clear clinical benefit are some of the reasons that could explain the gap between theory and practice. In this review, after a brief report of epidemiologic data and specificities of VTE in elderly patients, the authors discuss the available results of VTE primary prevention trials for elderly medical patients, the limitations of these data, and the challenges to improve the practice and to reduce the incidence of this frequent but preventable disease.Keywords: venous thromboembolism, prophylaxis, elderly patients, medical settings, review
format	article
author	Karine Lacut Grégoire Le Gal Dominique Mottier
author_facet	Karine Lacut Grégoire Le Gal Dominique Mottier
author_sort	Karine Lacut
title	Primary prevention of venous thromboembolism in elderly medical patients
title_short	Primary prevention of venous thromboembolism in elderly medical patients
title_full	Primary prevention of venous thromboembolism in elderly medical patients
title_fullStr	Primary prevention of venous thromboembolism in elderly medical patients
title_full_unstemmed	Primary prevention of venous thromboembolism in elderly medical patients
title_sort	primary prevention of venous thromboembolism in elderly medical patients
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/ec4a73c3bce841038a92d70d493da04a
work_keys_str_mv	AT karinelacut primarypreventionofvenousthromboembolisminelderlymedicalpatients AT greacutegoirelegal primarypreventionofvenousthromboembolisminelderlymedicalpatients AT dominiquemottier primarypreventionofvenousthromboembolisminelderlymedicalpatients
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Primary prevention of venous thromboembolism in elderly medical patients

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