p53 dynamics vary between tissues and are linked with radiation sensitivity

p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.

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Autores principales:	Jacob Stewart-Ornstein, Yoshiko Iwamoto, Miles A. Miller, Mark A. Prytyskach, Stephane Ferretti, Philipp Holzer, Joerg Kallen, Pascal Furet, Ashwini Jambhekar, William C. Forrester, Ralph Weissleder, Galit Lahav
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec4f9099e0ec49f6920b6fbb19143619
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spelling	oai:doaj.org-article:ec4f9099e0ec49f6920b6fbb191436192021-12-02T14:10:57Zp53 dynamics vary between tissues and are linked with radiation sensitivity10.1038/s41467-021-21145-z2041-1723https://doaj.org/article/ec4f9099e0ec49f6920b6fbb191436192021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21145-zhttps://doaj.org/toc/2041-1723p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.Jacob Stewart-OrnsteinYoshiko IwamotoMiles A. MillerMark A. PrytyskachStephane FerrettiPhilipp HolzerJoerg KallenPascal FuretAshwini JambhekarWilliam C. ForresterRalph WeisslederGalit LahavNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacob Stewart-Ornstein Yoshiko Iwamoto Miles A. Miller Mark A. Prytyskach Stephane Ferretti Philipp Holzer Joerg Kallen Pascal Furet Ashwini Jambhekar William C. Forrester Ralph Weissleder Galit Lahav p53 dynamics vary between tissues and are linked with radiation sensitivity
description	p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.
format	article
author	Jacob Stewart-Ornstein Yoshiko Iwamoto Miles A. Miller Mark A. Prytyskach Stephane Ferretti Philipp Holzer Joerg Kallen Pascal Furet Ashwini Jambhekar William C. Forrester Ralph Weissleder Galit Lahav
author_facet	Jacob Stewart-Ornstein Yoshiko Iwamoto Miles A. Miller Mark A. Prytyskach Stephane Ferretti Philipp Holzer Joerg Kallen Pascal Furet Ashwini Jambhekar William C. Forrester Ralph Weissleder Galit Lahav
author_sort	Jacob Stewart-Ornstein
title	p53 dynamics vary between tissues and are linked with radiation sensitivity
title_short	p53 dynamics vary between tissues and are linked with radiation sensitivity
title_full	p53 dynamics vary between tissues and are linked with radiation sensitivity
title_fullStr	p53 dynamics vary between tissues and are linked with radiation sensitivity
title_full_unstemmed	p53 dynamics vary between tissues and are linked with radiation sensitivity
title_sort	p53 dynamics vary between tissues and are linked with radiation sensitivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec4f9099e0ec49f6920b6fbb19143619
work_keys_str_mv	AT jacobstewartornstein p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT yoshikoiwamoto p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT milesamiller p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT markaprytyskach p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT stephaneferretti p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT philippholzer p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT joergkallen p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT pascalfuret p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT ashwinijambhekar p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT williamcforrester p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT ralphweissleder p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity AT galitlahav p53dynamicsvarybetweentissuesandarelinkedwithradiationsensitivity
_version_	1718391878815055872

p53 dynamics vary between tissues and are linked with radiation sensitivity

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