Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori

The small RNA RepG modulates expression of chemotaxis receptor TlpB in Helicobacter pylori by targeting a length-variable G-repeat in the tlpB mRNA. Here, Pernitzsch et al. show that RepG also gradually controls lipopolysaccharide biosynthesis, antibiotic susceptibility, and in-vivo colonization of...

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Autores principales:	Sandy R. Pernitzsch, Mona Alzheimer, Belinda U. Bremer, Marie Robbe-Saule, Hilde De Reuse, Cynthia M. Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec5072b7e69d4b0a86fde7dfb982fd78
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spelling	oai:doaj.org-article:ec5072b7e69d4b0a86fde7dfb982fd782021-12-02T17:55:05ZSmall RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori10.1038/s41467-021-24689-22041-1723https://doaj.org/article/ec5072b7e69d4b0a86fde7dfb982fd782021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24689-2https://doaj.org/toc/2041-1723The small RNA RepG modulates expression of chemotaxis receptor TlpB in Helicobacter pylori by targeting a length-variable G-repeat in the tlpB mRNA. Here, Pernitzsch et al. show that RepG also gradually controls lipopolysaccharide biosynthesis, antibiotic susceptibility, and in-vivo colonization of the stomach, by regulating a gene that is co-transcribed with tlpB.Sandy R. PernitzschMona AlzheimerBelinda U. BremerMarie Robbe-SauleHilde De ReuseCynthia M. SharmaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandy R. Pernitzsch Mona Alzheimer Belinda U. Bremer Marie Robbe-Saule Hilde De Reuse Cynthia M. Sharma Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori
description	The small RNA RepG modulates expression of chemotaxis receptor TlpB in Helicobacter pylori by targeting a length-variable G-repeat in the tlpB mRNA. Here, Pernitzsch et al. show that RepG also gradually controls lipopolysaccharide biosynthesis, antibiotic susceptibility, and in-vivo colonization of the stomach, by regulating a gene that is co-transcribed with tlpB.
format	article
author	Sandy R. Pernitzsch Mona Alzheimer Belinda U. Bremer Marie Robbe-Saule Hilde De Reuse Cynthia M. Sharma
author_facet	Sandy R. Pernitzsch Mona Alzheimer Belinda U. Bremer Marie Robbe-Saule Hilde De Reuse Cynthia M. Sharma
author_sort	Sandy R. Pernitzsch
title	Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori
title_short	Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori
title_full	Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori
title_fullStr	Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori
title_full_unstemmed	Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori
title_sort	small rna mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in helicobacter pylori
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec5072b7e69d4b0a86fde7dfb982fd78
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Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori

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