Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis
Background: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to...
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2021
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oai:doaj.org-article:ec5094ff58a84b728868a44ec9c0cac92021-11-11T16:26:55ZAre Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis10.3390/ijerph1821112991660-46011661-7827https://doaj.org/article/ec5094ff58a84b728868a44ec9c0cac92021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11299https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. Methods: Two randomized groups of hemodialysis patients: control (CTL, <i>n</i> = 76/F36; 66.33 ± 3.88 years) and RT (<i>n</i> = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes—SF36), and Beck Depression Inventory was applied. Results: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; <i>p =</i> 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; <i>p =</i> 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT,680.8 ± 225.2 vs. CTL,589.5 ± 195.9; <i>p =</i> 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; <i>p =</i> 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; <i>p =</i> 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; <i>p =</i> 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; <i>p =</i> 0.001). Quality of life and mental health increased (<i>p =</i> 0.001) for RT, but did not change for CTL (<i>p =</i> 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip (<i>p</i> = 0.001). Conclusions: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients.Lysleine Alves DeusHugo de Luca CorrêaRodrigo Vanerson Passos NevesAndrea Lucena ReisFernando Sousa HonoratoVictor Lopes SilvaMichel Kendy SouzaThaís Branquinho de AraújoLucas Santos de Gusmão AlvesCaio Victor SousaThaís Lucena ReisLucas Soares de AguiarHerbert Gustavo SimõesJonato PrestesGislane Ferreira MeloThiago Santos RosaMDPI AGarticlequality of lifeSF-36redox balanceneuroprotectiondepressionMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11299, p 11299 (2021) |
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DOAJ |
| language |
EN |
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quality of life SF-36 redox balance neuroprotection depression Medicine R |
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quality of life SF-36 redox balance neuroprotection depression Medicine R Lysleine Alves Deus Hugo de Luca Corrêa Rodrigo Vanerson Passos Neves Andrea Lucena Reis Fernando Sousa Honorato Victor Lopes Silva Michel Kendy Souza Thaís Branquinho de Araújo Lucas Santos de Gusmão Alves Caio Victor Sousa Thaís Lucena Reis Lucas Soares de Aguiar Herbert Gustavo Simões Jonato Prestes Gislane Ferreira Melo Thiago Santos Rosa Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis |
| description |
Background: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. Methods: Two randomized groups of hemodialysis patients: control (CTL, <i>n</i> = 76/F36; 66.33 ± 3.88 years) and RT (<i>n</i> = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes—SF36), and Beck Depression Inventory was applied. Results: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; <i>p =</i> 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; <i>p =</i> 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT,680.8 ± 225.2 vs. CTL,589.5 ± 195.9; <i>p =</i> 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; <i>p =</i> 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; <i>p =</i> 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; <i>p =</i> 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; <i>p =</i> 0.001). Quality of life and mental health increased (<i>p =</i> 0.001) for RT, but did not change for CTL (<i>p =</i> 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip (<i>p</i> = 0.001). Conclusions: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients. |
| format |
article |
| author |
Lysleine Alves Deus Hugo de Luca Corrêa Rodrigo Vanerson Passos Neves Andrea Lucena Reis Fernando Sousa Honorato Victor Lopes Silva Michel Kendy Souza Thaís Branquinho de Araújo Lucas Santos de Gusmão Alves Caio Victor Sousa Thaís Lucena Reis Lucas Soares de Aguiar Herbert Gustavo Simões Jonato Prestes Gislane Ferreira Melo Thiago Santos Rosa |
| author_facet |
Lysleine Alves Deus Hugo de Luca Corrêa Rodrigo Vanerson Passos Neves Andrea Lucena Reis Fernando Sousa Honorato Victor Lopes Silva Michel Kendy Souza Thaís Branquinho de Araújo Lucas Santos de Gusmão Alves Caio Victor Sousa Thaís Lucena Reis Lucas Soares de Aguiar Herbert Gustavo Simões Jonato Prestes Gislane Ferreira Melo Thiago Santos Rosa |
| author_sort |
Lysleine Alves Deus |
| title |
Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis |
| title_short |
Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis |
| title_full |
Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis |
| title_fullStr |
Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis |
| title_full_unstemmed |
Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axis |
| title_sort |
are resistance training-induced bdnf in hemodialysis patients associated with depressive symptoms, quality of life, antioxidant capacity, and muscle strength? an insight for the muscle–brain–renal axis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/ec5094ff58a84b728868a44ec9c0cac9 |
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