Role of stilbenes against insulin resistance: A review

Abstract Insulin resistance (IR) is a state characterized by the inability of tissues to utilize blood glucose particularly liver, muscle, and adipose tissues resulting in hyperglycemia and hyperinsulinemia. A close relationship exists between IR and the development of type 2 diabetes (T2D). Therefo...

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Autores principales: Shazmeen, Iahtisham‐Ul Haq, Muhammad Shahid Riaz Rajoka, Muhmmad Asim Shabbir, Muhammad Umair, Inam‐u llah, Muhammad Faisal Manzoor, Arash Nemat, Muhammad Abid, Moazzam Rafiq Khan, Rana Muhammad Aadil
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Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/ec569058c5d34c5fb07f0798d856e9b8
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spelling oai:doaj.org-article:ec569058c5d34c5fb07f0798d856e9b82021-11-04T13:06:43ZRole of stilbenes against insulin resistance: A review2048-717710.1002/fsn3.2553https://doaj.org/article/ec569058c5d34c5fb07f0798d856e9b82021-11-01T00:00:00Zhttps://doi.org/10.1002/fsn3.2553https://doaj.org/toc/2048-7177Abstract Insulin resistance (IR) is a state characterized by the inability of tissues to utilize blood glucose particularly liver, muscle, and adipose tissues resulting in hyperglycemia and hyperinsulinemia. A close relationship exists between IR and the development of type 2 diabetes (T2D). Therefore, therapeutic approaches to treat IR also improve T2D simultaneously. Scientific evidence has highlighted the major role of inflammatory cytokines, reactive oxygen species (ROS), environmental & genetic factors, and auto‐immune disorders in the pathophysiology of IR. Among therapeutic remedies, nutraceuticals like polyphenols are being used widely to ameliorate IR due to their safer nature compared to pharmaceutics. Stilbenes are considered important metabolically active polyphenols currently under the limelight of research to cope with IR. In this review, efforts are made to elucidate cellular and subcellular mechanisms influenced by stilbenes including modulating insulin signaling cascade, correcting glucose transport pathways, lowering postprandial glucose levels, and protecting β‐cell damage and its effects on the hyperactive immune system and proinflammatory cytokines to attenuate IR. Furthermore, future directions to further the research in stilbenes as a strong candidate against IR are included so that concrete recommendation for their use in humans is made.ShazmeenIahtisham‐Ul HaqMuhammad Shahid Riaz RajokaMuhmmad Asim ShabbirMuhammad UmairInam‐u llahMuhammad Faisal ManzoorArash NematMuhammad AbidMoazzam Rafiq KhanRana Muhammad AadilWileyarticlebiological pathwaysinsulin resistanceresveratroltype 2 diabetes mellitusNutrition. Foods and food supplyTX341-641ENFood Science & Nutrition, Vol 9, Iss 11, Pp 6389-6405 (2021)
institution DOAJ
collection DOAJ
language EN
topic biological pathways
insulin resistance
resveratrol
type 2 diabetes mellitus
Nutrition. Foods and food supply
TX341-641
spellingShingle biological pathways
insulin resistance
resveratrol
type 2 diabetes mellitus
Nutrition. Foods and food supply
TX341-641
Shazmeen
Iahtisham‐Ul Haq
Muhammad Shahid Riaz Rajoka
Muhmmad Asim Shabbir
Muhammad Umair
Inam‐u llah
Muhammad Faisal Manzoor
Arash Nemat
Muhammad Abid
Moazzam Rafiq Khan
Rana Muhammad Aadil
Role of stilbenes against insulin resistance: A review
description Abstract Insulin resistance (IR) is a state characterized by the inability of tissues to utilize blood glucose particularly liver, muscle, and adipose tissues resulting in hyperglycemia and hyperinsulinemia. A close relationship exists between IR and the development of type 2 diabetes (T2D). Therefore, therapeutic approaches to treat IR also improve T2D simultaneously. Scientific evidence has highlighted the major role of inflammatory cytokines, reactive oxygen species (ROS), environmental & genetic factors, and auto‐immune disorders in the pathophysiology of IR. Among therapeutic remedies, nutraceuticals like polyphenols are being used widely to ameliorate IR due to their safer nature compared to pharmaceutics. Stilbenes are considered important metabolically active polyphenols currently under the limelight of research to cope with IR. In this review, efforts are made to elucidate cellular and subcellular mechanisms influenced by stilbenes including modulating insulin signaling cascade, correcting glucose transport pathways, lowering postprandial glucose levels, and protecting β‐cell damage and its effects on the hyperactive immune system and proinflammatory cytokines to attenuate IR. Furthermore, future directions to further the research in stilbenes as a strong candidate against IR are included so that concrete recommendation for their use in humans is made.
format article
author Shazmeen
Iahtisham‐Ul Haq
Muhammad Shahid Riaz Rajoka
Muhmmad Asim Shabbir
Muhammad Umair
Inam‐u llah
Muhammad Faisal Manzoor
Arash Nemat
Muhammad Abid
Moazzam Rafiq Khan
Rana Muhammad Aadil
author_facet Shazmeen
Iahtisham‐Ul Haq
Muhammad Shahid Riaz Rajoka
Muhmmad Asim Shabbir
Muhammad Umair
Inam‐u llah
Muhammad Faisal Manzoor
Arash Nemat
Muhammad Abid
Moazzam Rafiq Khan
Rana Muhammad Aadil
author_sort Shazmeen
title Role of stilbenes against insulin resistance: A review
title_short Role of stilbenes against insulin resistance: A review
title_full Role of stilbenes against insulin resistance: A review
title_fullStr Role of stilbenes against insulin resistance: A review
title_full_unstemmed Role of stilbenes against insulin resistance: A review
title_sort role of stilbenes against insulin resistance: a review
publisher Wiley
publishDate 2021
url https://doaj.org/article/ec569058c5d34c5fb07f0798d856e9b8
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