A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab

Eosinophilic otitis media (EOM) is an intractable otitis media that is mostly associated with bronchial asthma. Middle ear effusion is highly viscous and contains many eosinophils. Surgical interventions, such as tympanoplasty and mastoidectomy, are usually contraindicated for patients with EOM beca...

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Autores principales:	Saori Kikuchi, Saeko Yoshida, Tomonori Sugiyama, Yukiko Iino
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Eosinophilic otitis media Dupilumab Anti-Interleukin-4 receptor therapy Biological drug Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/ec58b6cb31d9496a9203712bc8f38271
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spelling	oai:doaj.org-article:ec58b6cb31d9496a9203712bc8f382712021-12-02T05:03:29ZA case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab2468-548810.1016/j.xocr.2021.100381https://doaj.org/article/ec58b6cb31d9496a9203712bc8f382712021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2468548821001223https://doaj.org/toc/2468-5488Eosinophilic otitis media (EOM) is an intractable otitis media that is mostly associated with bronchial asthma. Middle ear effusion is highly viscous and contains many eosinophils. Surgical interventions, such as tympanoplasty and mastoidectomy, are usually contraindicated for patients with EOM because of the high incidence of deafness and relapse of EOM after the operation. We report here a patient who was successfully treated with tympanoplasty with the use of dupilumab therapy. The patient was a 50-year-old woman with the granulation type of EOM who had a poor response to treatments for EOM, including systemic and topical use of corticosteroids and other biological drugs. After switching to add-on dupilumab therapy, the granulation tissue from the mesotympanum gradually decreased and no middle ear effusion was found. The severity score of EOM and temporal bone computed tomographic findings were dramatically improved after dupilumab therapy. Tympanoplasty was then performed 13 months after the initiation of dupilumab therapy. The postoperative course was excellent without deterioration of the bone conduction hearing level or relapse of EOM for 1 year. Tympanoplasty/mastoidectomy for EOM is currently indicated if patients show a good response to biological drugs for a long time.Saori KikuchiSaeko YoshidaTomonori SugiyamaYukiko IinoElsevierarticleEosinophilic otitis mediaDupilumabAnti-Interleukin-4 receptor therapyBiological drugOtorhinolaryngologyRF1-547ENOtolaryngology Case Reports, Vol 21, Iss , Pp 100381- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Eosinophilic otitis media Dupilumab Anti-Interleukin-4 receptor therapy Biological drug Otorhinolaryngology RF1-547
spellingShingle	Eosinophilic otitis media Dupilumab Anti-Interleukin-4 receptor therapy Biological drug Otorhinolaryngology RF1-547 Saori Kikuchi Saeko Yoshida Tomonori Sugiyama Yukiko Iino A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
description	Eosinophilic otitis media (EOM) is an intractable otitis media that is mostly associated with bronchial asthma. Middle ear effusion is highly viscous and contains many eosinophils. Surgical interventions, such as tympanoplasty and mastoidectomy, are usually contraindicated for patients with EOM because of the high incidence of deafness and relapse of EOM after the operation. We report here a patient who was successfully treated with tympanoplasty with the use of dupilumab therapy. The patient was a 50-year-old woman with the granulation type of EOM who had a poor response to treatments for EOM, including systemic and topical use of corticosteroids and other biological drugs. After switching to add-on dupilumab therapy, the granulation tissue from the mesotympanum gradually decreased and no middle ear effusion was found. The severity score of EOM and temporal bone computed tomographic findings were dramatically improved after dupilumab therapy. Tympanoplasty was then performed 13 months after the initiation of dupilumab therapy. The postoperative course was excellent without deterioration of the bone conduction hearing level or relapse of EOM for 1 year. Tympanoplasty/mastoidectomy for EOM is currently indicated if patients show a good response to biological drugs for a long time.
format	article
author	Saori Kikuchi Saeko Yoshida Tomonori Sugiyama Yukiko Iino
author_facet	Saori Kikuchi Saeko Yoshida Tomonori Sugiyama Yukiko Iino
author_sort	Saori Kikuchi
title	A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
title_short	A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
title_full	A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
title_fullStr	A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
title_full_unstemmed	A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
title_sort	case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ec58b6cb31d9496a9203712bc8f38271
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A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab

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