IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY

We have previously shown that acute traumatic brain injury (TBI) is accompanied by increased level of circulating bone marrow progenitors, and favorable outcome is associated with early mobilization of CD34+CD45+ hematopoietic progenitor cells (HP). The present study was aimed at investigating wheth...

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Autores principales:	V. A. Chernykh, N. V. Pronkina, E. Ya. Shevela, V. V. Stupak, S. S. Rabinovich, E. R. Chernykh, A. A. Ostanin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	circulating bone marrow progenitors cd34+cd45+ cells cell mobilization immunomodulation traumatic brain injury Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ec5bd4d066534bc287aeacaeaa0ab03a
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spelling	oai:doaj.org-article:ec5bd4d066534bc287aeacaeaa0ab03a2021-11-18T08:03:44ZIMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY1563-06252313-741X10.15789/1563-0625-2014-6-577-586https://doaj.org/article/ec5bd4d066534bc287aeacaeaa0ab03a2015-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/771https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have previously shown that acute traumatic brain injury (TBI) is accompanied by increased level of circulating bone marrow progenitors, and favorable outcome is associated with early mobilization of CD34+CD45+ hematopoietic progenitor cells (HP). The present study was aimed at investigating whether patients with early HP mobilization differed from those with mobilization failure by systemic inflammatory reaction and immune parameters. The TBI patients were characterized by increased levels of serum C-reactive protein (CRP), IL-1в, IL-6, IL-8, MCP-1, G-CSF and IL-1ra indicative for presence of systemic inflammatory response. Importantly, patients with lacking mobilization of early HPs were shown to have significantly higher serum levels of CRP, MCP-1, MIP-1в, and G-CSF and a lower level of VEGF. In addition, patients with lack of early HP mobilization differed by significantly lower absolute number of lymphocytes, CD3+ T cells, CD4+ T cells, CD16+ NK cells and proliferative response of mononuclear cells to stimulation with ConA as well as by 4-fold higher rate of infectious complications compared with the opposite group. These data suggest that correlation of early mobilization of CD34+CD45+ cells with a favorable outcome in TBI patients may be partially mediated by anti-inflammatory and immunomodulatory effects of circulating bone marrow progenitors.V. A. ChernykhN. V. PronkinaE. Ya. ShevelaV. V. StupakS. S. RabinovichE. R. ChernykhA. A. OstaninSPb RAACIarticlecirculating bone marrow progenitorscd34+cd45+ cellscell mobilizationimmunomodulationtraumatic brain injuryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 6, Pp 577-586 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	circulating bone marrow progenitors cd34+cd45+ cells cell mobilization immunomodulation traumatic brain injury Immunologic diseases. Allergy RC581-607
spellingShingle	circulating bone marrow progenitors cd34+cd45+ cells cell mobilization immunomodulation traumatic brain injury Immunologic diseases. Allergy RC581-607 V. A. Chernykh N. V. Pronkina E. Ya. Shevela V. V. Stupak S. S. Rabinovich E. R. Chernykh A. A. Ostanin IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY
description	We have previously shown that acute traumatic brain injury (TBI) is accompanied by increased level of circulating bone marrow progenitors, and favorable outcome is associated with early mobilization of CD34+CD45+ hematopoietic progenitor cells (HP). The present study was aimed at investigating whether patients with early HP mobilization differed from those with mobilization failure by systemic inflammatory reaction and immune parameters. The TBI patients were characterized by increased levels of serum C-reactive protein (CRP), IL-1в, IL-6, IL-8, MCP-1, G-CSF and IL-1ra indicative for presence of systemic inflammatory response. Importantly, patients with lacking mobilization of early HPs were shown to have significantly higher serum levels of CRP, MCP-1, MIP-1в, and G-CSF and a lower level of VEGF. In addition, patients with lack of early HP mobilization differed by significantly lower absolute number of lymphocytes, CD3+ T cells, CD4+ T cells, CD16+ NK cells and proliferative response of mononuclear cells to stimulation with ConA as well as by 4-fold higher rate of infectious complications compared with the opposite group. These data suggest that correlation of early mobilization of CD34+CD45+ cells with a favorable outcome in TBI patients may be partially mediated by anti-inflammatory and immunomodulatory effects of circulating bone marrow progenitors.
format	article
author	V. A. Chernykh N. V. Pronkina E. Ya. Shevela V. V. Stupak S. S. Rabinovich E. R. Chernykh A. A. Ostanin
author_facet	V. A. Chernykh N. V. Pronkina E. Ya. Shevela V. V. Stupak S. S. Rabinovich E. R. Chernykh A. A. Ostanin
author_sort	V. A. Chernykh
title	IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY
title_short	IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY
title_full	IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY
title_fullStr	IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY
title_full_unstemmed	IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY
title_sort	immunomodulatory effect of circulating bone marrow progenitors as a possible mechanism of neuroprotection in traumatic brain injury
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/ec5bd4d066534bc287aeacaeaa0ab03a
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_version_	1718422454502686720

IMMUNOMODULATORY EFFECT OF CIRCULATING BONE MARROW PROGENITORS AS A POSSIBLE MECHANISM OF NEUROPROTECTION IN TRAUMATIC BRAIN INJURY

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