CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN

Objective: To determine the clinical and laboratory features during the disease course in patients of anti cytoplasmic antibody (ANCA) associated vasculitis in Pakistani patients presenting to a tertiary care center. Study Design: Case series. Place and Duration of Study: Fatima Memorial Hosp...

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Autores principales:	Muhammad Zeeshan Aslam, Asadullah kakkar, Haseeb Ahmed Khan, Saira Elaine Anwar khan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	anti cytoplasmic antibody associated vasculitis eosinophilic granulomatosis with polyangiitis granulomatosis with polyangiitis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ec5ca463969f475c9a8b9bf68358212e
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spelling	oai:doaj.org-article:ec5ca463969f475c9a8b9bf68358212e2021-11-05T03:44:48ZCLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN0030-96482411-8842https://doaj.org/article/ec5ca463969f475c9a8b9bf68358212e2021-02-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3157/3214https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the clinical and laboratory features during the disease course in patients of anti cytoplasmic antibody (ANCA) associated vasculitis in Pakistani patients presenting to a tertiary care center. Study Design: Case series. Place and Duration of Study: Fatima Memorial Hospital Shadman Lahore, from Dec 2018 to Mar 2019. Methodology: A collection of 20 patients regarding demographic data, constitutional symptoms, mucocutaneous symptoms and signs, upper respiratory symptoms, lower respiratory symptoms, orbital and ocular manifestation, cardiovascular, peripheral vascular manifestation, central and peripheral neurologic manifestation, abdominal manifestation and renal manifestation Results: Sixteen patients (80%) had a diagnosis of Granulomatosis with Polyangiitis, and 4 patients (20%) were of microscopic polyangiitis. The most common systemic involvement in descending order were constitutional symptoms (75%), ear nose and throat symptoms (50%), renal (50%), respiratory (45%), ocular (40%) and neurologic (40%). Most common laboratory abnormalities in our patients included leukocytosis (45%), anemia (35%), hematuria (50%), proteinuria (45%), and elevated serum creatinine (45%). Cytoplasmic-anti cytoplasmic antibody (C-ANCA) was positive in 11 (55%), all cases were of granulomatosis with polyangiitis, P-ANCA was positive in 5 (25%) of all patients, with 4 (100%) in Microscopic polyangiitis. Analysis of Granulomatosis with Polyangiitis according to gender and cytoplasmic-anti cytoplasmic antibody status showed correlation of renal involvement with cytoplasmic-anti cytoplasmic antibody status with statistical significance of p=0.036. Plain chest X-rays showed infiltrates in 2 (10%), nodularity 2 (10%), cavitation in 2 (10%), effusion in 1 (5%), and reticulonodular showing in 1 (5%) patients. High-resolution computed tomography findings included ground-glass opacification in 5............Muhammad Zeeshan AslamAsadullah kakkarHaseeb Ahmed KhanSaira Elaine Anwar khanArmy Medical College Rawalpindiarticleanti cytoplasmic antibody associated vasculitiseosinophilic granulomatosis with polyangiitisgranulomatosis with polyangiitisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 29-33 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti cytoplasmic antibody associated vasculitis eosinophilic granulomatosis with polyangiitis granulomatosis with polyangiitis Medicine R Medicine (General) R5-920
spellingShingle	anti cytoplasmic antibody associated vasculitis eosinophilic granulomatosis with polyangiitis granulomatosis with polyangiitis Medicine R Medicine (General) R5-920 Muhammad Zeeshan Aslam Asadullah kakkar Haseeb Ahmed Khan Saira Elaine Anwar khan CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN
description	Objective: To determine the clinical and laboratory features during the disease course in patients of anti cytoplasmic antibody (ANCA) associated vasculitis in Pakistani patients presenting to a tertiary care center. Study Design: Case series. Place and Duration of Study: Fatima Memorial Hospital Shadman Lahore, from Dec 2018 to Mar 2019. Methodology: A collection of 20 patients regarding demographic data, constitutional symptoms, mucocutaneous symptoms and signs, upper respiratory symptoms, lower respiratory symptoms, orbital and ocular manifestation, cardiovascular, peripheral vascular manifestation, central and peripheral neurologic manifestation, abdominal manifestation and renal manifestation Results: Sixteen patients (80%) had a diagnosis of Granulomatosis with Polyangiitis, and 4 patients (20%) were of microscopic polyangiitis. The most common systemic involvement in descending order were constitutional symptoms (75%), ear nose and throat symptoms (50%), renal (50%), respiratory (45%), ocular (40%) and neurologic (40%). Most common laboratory abnormalities in our patients included leukocytosis (45%), anemia (35%), hematuria (50%), proteinuria (45%), and elevated serum creatinine (45%). Cytoplasmic-anti cytoplasmic antibody (C-ANCA) was positive in 11 (55%), all cases were of granulomatosis with polyangiitis, P-ANCA was positive in 5 (25%) of all patients, with 4 (100%) in Microscopic polyangiitis. Analysis of Granulomatosis with Polyangiitis according to gender and cytoplasmic-anti cytoplasmic antibody status showed correlation of renal involvement with cytoplasmic-anti cytoplasmic antibody status with statistical significance of p=0.036. Plain chest X-rays showed infiltrates in 2 (10%), nodularity 2 (10%), cavitation in 2 (10%), effusion in 1 (5%), and reticulonodular showing in 1 (5%) patients. High-resolution computed tomography findings included ground-glass opacification in 5............
format	article
author	Muhammad Zeeshan Aslam Asadullah kakkar Haseeb Ahmed Khan Saira Elaine Anwar khan
author_facet	Muhammad Zeeshan Aslam Asadullah kakkar Haseeb Ahmed Khan Saira Elaine Anwar khan
author_sort	Muhammad Zeeshan Aslam
title	CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN
title_short	CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN
title_full	CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN
title_fullStr	CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN
title_full_unstemmed	CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN
title_sort	clinical and laboratory features of anca associated vasculitis: experience at a tertiary care hospital in lahore, pakistan
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/ec5ca463969f475c9a8b9bf68358212e
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CLINICAL AND LABORATORY FEATURES OF ANCA ASSOCIATED VASCULITIS: EXPERIENCE AT A TERTIARY CARE HOSPITAL IN LAHORE, PAKISTAN

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