Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia

Elizabete Viana de Freitas, Andréa Araújo Brandão, Roberto Pozzan, Maria Eliane Magalhães, Márcia Castier, Airton Pires BrandãoCardiology Department, Pedro Ernesto University Hospital, State University of Rio de Janeiro, BrazilObjecti...

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Autores principales:	Elizabete Viana de Freitas, Andréa Araújo Brandão, Roberto Pozzan, Maria Eliane Magalhães, Márcia Castier, Airton Pires Brandão
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ec63063ff3134f90983452fca6a70d37
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spelling	oai:doaj.org-article:ec63063ff3134f90983452fca6a70d372021-12-02T07:08:03ZStudy of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia1178-1998https://doaj.org/article/ec63063ff3134f90983452fca6a70d372008-09-01T00:00:00Zhttps://www.dovepress.com/study-of-the-intima-media-thickening-in-carotid-arteries-of-healthy-el-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Elizabete Viana de Freitas, Andréa Araújo Brandão, Roberto Pozzan, Maria Eliane Magalhães, Márcia Castier, Airton Pires BrandãoCardiology Department, Pedro Ernesto University Hospital, State University of Rio de Janeiro, BrazilObjective: The objective of this study was to assess the mean intima-media thickening of carotid arteries of elderly subjects, and its relationship with age, anthropometric measurements, high systolic blood pressure and dyslipidemia.Methods: In this investigation, 129 subjects were enrolled between 1995 and 1998, age ranging from 29 to 94 years. They were assigned to one of 4 groups, including 2 control groups (group I, of healthy younger subjects; group II of healthy elderly subjects). Groups III and IV included those who presented with isolated systolic hypertension (ISH), and ISH and dyslipidemia, respectively. All subjects were submitted to a medical interview, lab tests with measurement of cholesterol levels, electrocardiogram, and carotid ultrasound. The ultrasound included measurement of the intima-media thickening (IMT) of the carotid arteries, the right carotid artery (RCA) and left carotid artery (LCA), and assessment of the presence of plaques. Blood fat and glucose were measured by a standard method. The results were compared among the groups through statistical tests. The tests employed were: Chi-Square, Pearson’s and Likelihood Ratio, Student’s t, Mann-Whitney; ANOVA followed by Tukey’s test, Kruskal-Wallis nonparametric test, and test for multiple comparisons and Odds Ratio determination (OR).Results: In this investigation, a positive association was observed between aging and IMT. In relation to systolic hypertension, a significant association was observed with IMT (IMT-RCA p = 0.0034; IMT-LCA p = 0.0196; IMT-RLCA p = 0.0299), and with the presence of plaques (PlaqueR p = 0.0110; PlaqueL p = 0.0294; PlaqueRL p = 0.0040).Conclusion: This investigation evidenced the important role of aging in IMT, and of systolic hypertension in the IMT and presence of plaque. However, further studies are needed for a better understanding of the actual role of risk factors in aging.Keywords: aging, elderly, carotid arteries, high blood pressureElizabete Viana de FreitasAndréa Araújo BrandãoRoberto PozzanMaria Eliane MagalhãesMárcia CastierAirton Pires BrandãoDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 525-534 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Elizabete Viana de Freitas Andréa Araújo Brandão Roberto Pozzan Maria Eliane Magalhães Márcia Castier Airton Pires Brandão Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
description	Elizabete Viana de Freitas, Andréa Araújo Brandão, Roberto Pozzan, Maria Eliane Magalhães, Márcia Castier, Airton Pires BrandãoCardiology Department, Pedro Ernesto University Hospital, State University of Rio de Janeiro, BrazilObjective: The objective of this study was to assess the mean intima-media thickening of carotid arteries of elderly subjects, and its relationship with age, anthropometric measurements, high systolic blood pressure and dyslipidemia.Methods: In this investigation, 129 subjects were enrolled between 1995 and 1998, age ranging from 29 to 94 years. They were assigned to one of 4 groups, including 2 control groups (group I, of healthy younger subjects; group II of healthy elderly subjects). Groups III and IV included those who presented with isolated systolic hypertension (ISH), and ISH and dyslipidemia, respectively. All subjects were submitted to a medical interview, lab tests with measurement of cholesterol levels, electrocardiogram, and carotid ultrasound. The ultrasound included measurement of the intima-media thickening (IMT) of the carotid arteries, the right carotid artery (RCA) and left carotid artery (LCA), and assessment of the presence of plaques. Blood fat and glucose were measured by a standard method. The results were compared among the groups through statistical tests. The tests employed were: Chi-Square, Pearson’s and Likelihood Ratio, Student’s t, Mann-Whitney; ANOVA followed by Tukey’s test, Kruskal-Wallis nonparametric test, and test for multiple comparisons and Odds Ratio determination (OR).Results: In this investigation, a positive association was observed between aging and IMT. In relation to systolic hypertension, a significant association was observed with IMT (IMT-RCA p = 0.0034; IMT-LCA p = 0.0196; IMT-RLCA p = 0.0299), and with the presence of plaques (PlaqueR p = 0.0110; PlaqueL p = 0.0294; PlaqueRL p = 0.0040).Conclusion: This investigation evidenced the important role of aging in IMT, and of systolic hypertension in the IMT and presence of plaque. However, further studies are needed for a better understanding of the actual role of risk factors in aging.Keywords: aging, elderly, carotid arteries, high blood pressure
format	article
author	Elizabete Viana de Freitas Andréa Araújo Brandão Roberto Pozzan Maria Eliane Magalhães Márcia Castier Airton Pires Brandão
author_facet	Elizabete Viana de Freitas Andréa Araújo Brandão Roberto Pozzan Maria Eliane Magalhães Márcia Castier Airton Pires Brandão
author_sort	Elizabete Viana de Freitas
title	Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
title_short	Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
title_full	Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
title_fullStr	Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
title_full_unstemmed	Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
title_sort	study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/ec63063ff3134f90983452fca6a70d37
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Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia

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