Oxidative stress and its downstream signaling in aging eyes

María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pinazo-Durán MD, Gallego-Pinazo R, García-Medina JJ, Zanon-Moreno V, Nucci C, Dolz-Marco R, Martínez-Castillo S, Galbis-Estrada C, Marco-Ramirez C, Lopez-Gálvez MI, Galarreta DJ, Díaz-Llópis M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Oxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ec63489c0dca4319a23aa3d763f9eda5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec63489c0dca4319a23aa3d763f9eda5
record_format	dspace
spelling	oai:doaj.org-article:ec63489c0dca4319a23aa3d763f9eda52021-12-02T08:41:43ZOxidative stress and its downstream signaling in aging eyes1178-1998https://doaj.org/article/ec63489c0dca4319a23aa3d763f9eda52014-04-01T00:00:00Zhttps://www.dovepress.com/oxidative-stress-and-its-downstream-signaling-in-aging-eyes-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5University of Rome Tor Vergata, Rome, Italy; 6Instituto de Oftalmobiología Aplicada (IOBA), Valladolid, Spain Members of the Spanish Net of Ocular Pathology of the Instituto de Salud Carlos III (Madrid), OFTAREDBackground: Oxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury.Objective: We reviewed the role of OS and its downstream signaling in aging eyes.Methods: A search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy.Results: Clinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality. Studies with nutraceutic supplements in aging eye-related pathologies have also been reviewed.Conclusion: OS, nutritional status, and nutraceutic supplements have to be considered within the standards of care of older ophthalmologic patients. OS biomarkers and surrogate end points may help in managing the aging population with ocular diseases.Keywords: oxidative stress, eyes, aging, ophthalmic diseases, antioxidants, epidemiologyPinazo-Durán MDGallego-Pinazo RGarcía-Medina JJZanon-Moreno VNucci CDolz-Marco RMartínez-Castillo SGalbis-Estrada CMarco-Ramirez CLopez-Gálvez MIGalarreta DJDíaz-Llópis MDove Medical PressarticleOxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 637-652 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology. Geriatrics RC952-954.6
spellingShingle	Oxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology. Geriatrics RC952-954.6 Pinazo-Durán MD Gallego-Pinazo R García-Medina JJ Zanon-Moreno V Nucci C Dolz-Marco R Martínez-Castillo S Galbis-Estrada C Marco-Ramirez C Lopez-Gálvez MI Galarreta DJ Díaz-Llópis M Oxidative stress and its downstream signaling in aging eyes
description	María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5University of Rome Tor Vergata, Rome, Italy; 6Instituto de Oftalmobiología Aplicada (IOBA), Valladolid, Spain Members of the Spanish Net of Ocular Pathology of the Instituto de Salud Carlos III (Madrid), OFTAREDBackground: Oxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury.Objective: We reviewed the role of OS and its downstream signaling in aging eyes.Methods: A search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy.Results: Clinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality. Studies with nutraceutic supplements in aging eye-related pathologies have also been reviewed.Conclusion: OS, nutritional status, and nutraceutic supplements have to be considered within the standards of care of older ophthalmologic patients. OS biomarkers and surrogate end points may help in managing the aging population with ocular diseases.Keywords: oxidative stress, eyes, aging, ophthalmic diseases, antioxidants, epidemiology
format	article
author	Pinazo-Durán MD Gallego-Pinazo R García-Medina JJ Zanon-Moreno V Nucci C Dolz-Marco R Martínez-Castillo S Galbis-Estrada C Marco-Ramirez C Lopez-Gálvez MI Galarreta DJ Díaz-Llópis M
author_facet	Pinazo-Durán MD Gallego-Pinazo R García-Medina JJ Zanon-Moreno V Nucci C Dolz-Marco R Martínez-Castillo S Galbis-Estrada C Marco-Ramirez C Lopez-Gálvez MI Galarreta DJ Díaz-Llópis M
author_sort	Pinazo-Durán MD
title	Oxidative stress and its downstream signaling in aging eyes
title_short	Oxidative stress and its downstream signaling in aging eyes
title_full	Oxidative stress and its downstream signaling in aging eyes
title_fullStr	Oxidative stress and its downstream signaling in aging eyes
title_full_unstemmed	Oxidative stress and its downstream signaling in aging eyes
title_sort	oxidative stress and its downstream signaling in aging eyes
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/ec63489c0dca4319a23aa3d763f9eda5
work_keys_str_mv	AT pinazoduraacutenmd oxidativestressanditsdownstreamsignalinginagingeyes AT gallegopinazor oxidativestressanditsdownstreamsignalinginagingeyes AT garciacuteamedinajj oxidativestressanditsdownstreamsignalinginagingeyes AT zanonmorenov oxidativestressanditsdownstreamsignalinginagingeyes AT nuccic oxidativestressanditsdownstreamsignalinginagingeyes AT dolzmarcor oxidativestressanditsdownstreamsignalinginagingeyes AT martiacutenezcastillos oxidativestressanditsdownstreamsignalinginagingeyes AT galbisestradac oxidativestressanditsdownstreamsignalinginagingeyes AT marcoramirezc oxidativestressanditsdownstreamsignalinginagingeyes AT lopezgaacutelvezmi oxidativestressanditsdownstreamsignalinginagingeyes AT galarretadj oxidativestressanditsdownstreamsignalinginagingeyes AT diacuteazlloacutepism oxidativestressanditsdownstreamsignalinginagingeyes
_version_	1718398439338803200

Oxidative stress and its downstream signaling in aging eyes

Ejemplares similares