Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.

<h4>Background</h4>Pregnancy-associated malaria (PAM) causing maternal anemia and low birth weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected erythrocytes (iEs) can acquire various adhesive properties that mediate the clinical severity of malaria. Rec...

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Autores principales:	Nicaise Tuikue Ndam, Emmanuel Bischoff, Caroline Proux, Thomas Lavstsen, Ali Salanti, Juliette Guitard, Morten A Nielsen, Jean-Yves Coppée, Alioune Gaye, Thor Theander, Peter H David, Philippe Deloron
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec6609ca043b41779d99c411a09ba0dd
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spelling	oai:doaj.org-article:ec6609ca043b41779d99c411a09ba0dd2021-11-25T06:12:59ZPlasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.1932-620310.1371/journal.pone.0001855https://doaj.org/article/ec6609ca043b41779d99c411a09ba0dd2008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18365010/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Pregnancy-associated malaria (PAM) causing maternal anemia and low birth weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected erythrocytes (iEs) can acquire various adhesive properties that mediate the clinical severity of malaria. Recent advances on the molecular basis of virulence and immune evasion have helped identify var2csa as a PAM-specific var gene.<h4>Methodology/principal findings</h4>The present study presents a genome-wide microarray transcript analysis of 18 P. falciparum parasite isolates freshly collected from the placenta. The proportion of PAM over-expressed genes located in subtelomeric regions as well as that of PAM over-expressed genes predicted to be exported were higher than expected compared to the whole genome. The identification of novel parasite molecules with specificity to PAM and which are likely involved in host-pathogen interactions and placental tropism is described. One of these proteins, PFI1785w, was further characterized as the product of a two-exon PHIST gene, and was more often recognized by serum samples from P. falciparum-exposed women than from men.<h4>Conclusions/significance</h4>These findings suggest that other parasite proteins, such as PFI1785w, may contribute beside VAR2CSA to the pathogenesis of PAM. These data may be very valuable for future vaccine development.Nicaise Tuikue NdamEmmanuel BischoffCaroline ProuxThomas LavstsenAli SalantiJuliette GuitardMorten A NielsenJean-Yves CoppéeAlioune GayeThor TheanderPeter H DavidPhilippe DeloronPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 3, p e1855 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nicaise Tuikue Ndam Emmanuel Bischoff Caroline Proux Thomas Lavstsen Ali Salanti Juliette Guitard Morten A Nielsen Jean-Yves Coppée Alioune Gaye Thor Theander Peter H David Philippe Deloron Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
description	<h4>Background</h4>Pregnancy-associated malaria (PAM) causing maternal anemia and low birth weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected erythrocytes (iEs) can acquire various adhesive properties that mediate the clinical severity of malaria. Recent advances on the molecular basis of virulence and immune evasion have helped identify var2csa as a PAM-specific var gene.<h4>Methodology/principal findings</h4>The present study presents a genome-wide microarray transcript analysis of 18 P. falciparum parasite isolates freshly collected from the placenta. The proportion of PAM over-expressed genes located in subtelomeric regions as well as that of PAM over-expressed genes predicted to be exported were higher than expected compared to the whole genome. The identification of novel parasite molecules with specificity to PAM and which are likely involved in host-pathogen interactions and placental tropism is described. One of these proteins, PFI1785w, was further characterized as the product of a two-exon PHIST gene, and was more often recognized by serum samples from P. falciparum-exposed women than from men.<h4>Conclusions/significance</h4>These findings suggest that other parasite proteins, such as PFI1785w, may contribute beside VAR2CSA to the pathogenesis of PAM. These data may be very valuable for future vaccine development.
format	article
author	Nicaise Tuikue Ndam Emmanuel Bischoff Caroline Proux Thomas Lavstsen Ali Salanti Juliette Guitard Morten A Nielsen Jean-Yves Coppée Alioune Gaye Thor Theander Peter H David Philippe Deloron
author_facet	Nicaise Tuikue Ndam Emmanuel Bischoff Caroline Proux Thomas Lavstsen Ali Salanti Juliette Guitard Morten A Nielsen Jean-Yves Coppée Alioune Gaye Thor Theander Peter H David Philippe Deloron
author_sort	Nicaise Tuikue Ndam
title	Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
title_short	Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
title_full	Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
title_fullStr	Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
title_full_unstemmed	Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
title_sort	plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/ec6609ca043b41779d99c411a09ba0dd
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Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.

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