Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain

Soubir Basak1, David Brogan2, Hans Dietrich2, Rogers Ritter3, Ralph G Dacey2, Pratim Biswas11Aerosol and Air Quality Research Laboratory, Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA; 2Department of Neurological Surgery, Washing...

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Autores principales:	Soubir Basak, David Brogan, Hans Dietrich, Rogers Ritter, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ec699d576a3942119b44ddb49e7c7a1b
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spelling	oai:doaj.org-article:ec699d576a3942119b44ddb49e7c7a1b2021-12-02T06:30:00ZTransport characteristics of nanoparticle-based ferrofluids in a gel model of the brain1176-91141178-2013https://doaj.org/article/ec699d576a3942119b44ddb49e7c7a1b2009-04-01T00:00:00Zhttp://www.dovepress.com/transport-characteristics-of-nanoparticle-based-ferrofluids-in-a-gel-m-a3011https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Soubir Basak1, David Brogan2, Hans Dietrich2, Rogers Ritter3, Ralph G Dacey2, Pratim Biswas11Aerosol and Air Quality Research Laboratory, Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA; 2Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA; 3Stereotaxis Inc., St. Louis, MO, USAAbstract: A current advance in nanotechnology is the selective targeting of therapeutics by external magnetic field-guided delivery. This is an important area of research in medicine. The use of magnetic forces results in the formation of agglomerated structures in the field region. The transport characteristics of these agglomerated structures are explored. A nonintrusive method based on in situ light-scattering techniques is used to characterize the velocity of such particles in a magnetic field gradient. A transport model for the chain-like agglomerates is developed based on these experimental observations. The transport characteristics of magnetic nanoparticle drug carriers are then explored in gel-based simulated models of the brain. Results of such measurements demonstrate decreased diffusion of magnetic nanoparticles when placed in a high magnetic field gradient. &nbsp;Keywords: nanoparticle ferrofluid, gel-brain model, drug delivery, magnetic agglomeration, transport, magnetic fields Soubir BasakDavid BroganHans DietrichRogers Ritteret al.Dove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 9-26 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Soubir Basak David Brogan Hans Dietrich Rogers Ritter et al. Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
description	Soubir Basak1, David Brogan2, Hans Dietrich2, Rogers Ritter3, Ralph G Dacey2, Pratim Biswas11Aerosol and Air Quality Research Laboratory, Department of Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA; 2Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA; 3Stereotaxis Inc., St. Louis, MO, USAAbstract: A current advance in nanotechnology is the selective targeting of therapeutics by external magnetic field-guided delivery. This is an important area of research in medicine. The use of magnetic forces results in the formation of agglomerated structures in the field region. The transport characteristics of these agglomerated structures are explored. A nonintrusive method based on in situ light-scattering techniques is used to characterize the velocity of such particles in a magnetic field gradient. A transport model for the chain-like agglomerates is developed based on these experimental observations. The transport characteristics of magnetic nanoparticle drug carriers are then explored in gel-based simulated models of the brain. Results of such measurements demonstrate decreased diffusion of magnetic nanoparticles when placed in a high magnetic field gradient. &nbsp;Keywords: nanoparticle ferrofluid, gel-brain model, drug delivery, magnetic agglomeration, transport, magnetic fields
format	article
author	Soubir Basak David Brogan Hans Dietrich Rogers Ritter et al.
author_facet	Soubir Basak David Brogan Hans Dietrich Rogers Ritter et al.
author_sort	Soubir Basak
title	Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
title_short	Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
title_full	Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
title_fullStr	Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
title_full_unstemmed	Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
title_sort	transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/ec699d576a3942119b44ddb49e7c7a1b
work_keys_str_mv	AT soubirbasak transportcharacteristicsofnanoparticlebasedferrofluidsinagelmodelofthebrain AT davidbrogan transportcharacteristicsofnanoparticlebasedferrofluidsinagelmodelofthebrain AT hansdietrich transportcharacteristicsofnanoparticlebasedferrofluidsinagelmodelofthebrain AT rogersritter transportcharacteristicsofnanoparticlebasedferrofluidsinagelmodelofthebrain AT etal transportcharacteristicsofnanoparticlebasedferrofluidsinagelmodelofthebrain
_version_	1718399908984127488

Transport characteristics of nanoparticle-based ferrofluids in a gel model of the brain

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