The Role of Sphingolipid Metabolism in Bone Remodeling

Emerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obta...

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Autores principales: Tang Qi, Liao Li, Tian Weidong
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
S1P
Acceso en línea:https://doaj.org/article/ec6c9c78af704b0f9e1dbaac84989f38
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spelling oai:doaj.org-article:ec6c9c78af704b0f9e1dbaac84989f382021-12-01T11:39:05ZThe Role of Sphingolipid Metabolism in Bone Remodeling2296-634X10.3389/fcell.2021.752540https://doaj.org/article/ec6c9c78af704b0f9e1dbaac84989f382021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.752540/fullhttps://doaj.org/toc/2296-634XEmerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obtain new insights into the role sphingolipid played on skeletal remodeling. This review summarizes studies or understandings of the crosstalk between sphingomyelin, ceramide, and sphingosine-1-phosphate (S1P) of sphingolipids family and the cells, especially osteoblasts and osteoclasts of the bone through which bone is remodeled during life constantly. This review also shows agonists and antagonists of S1P as possible therapeutic options and opportunities on bone diseases.Tang QiLiao LiTian WeidongFrontiers Media S.A.articlesphingolipidbone remodelingosteoblastosteoclastS1PBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution DOAJ
collection DOAJ
language EN
topic sphingolipid
bone remodeling
osteoblast
osteoclast
S1P
Biology (General)
QH301-705.5
spellingShingle sphingolipid
bone remodeling
osteoblast
osteoclast
S1P
Biology (General)
QH301-705.5
Tang Qi
Liao Li
Tian Weidong
The Role of Sphingolipid Metabolism in Bone Remodeling
description Emerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obtain new insights into the role sphingolipid played on skeletal remodeling. This review summarizes studies or understandings of the crosstalk between sphingomyelin, ceramide, and sphingosine-1-phosphate (S1P) of sphingolipids family and the cells, especially osteoblasts and osteoclasts of the bone through which bone is remodeled during life constantly. This review also shows agonists and antagonists of S1P as possible therapeutic options and opportunities on bone diseases.
format article
author Tang Qi
Liao Li
Tian Weidong
author_facet Tang Qi
Liao Li
Tian Weidong
author_sort Tang Qi
title The Role of Sphingolipid Metabolism in Bone Remodeling
title_short The Role of Sphingolipid Metabolism in Bone Remodeling
title_full The Role of Sphingolipid Metabolism in Bone Remodeling
title_fullStr The Role of Sphingolipid Metabolism in Bone Remodeling
title_full_unstemmed The Role of Sphingolipid Metabolism in Bone Remodeling
title_sort role of sphingolipid metabolism in bone remodeling
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/ec6c9c78af704b0f9e1dbaac84989f38
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