The Role of Sphingolipid Metabolism in Bone Remodeling

Emerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obta...

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Auteurs principaux:	Tang Qi, Liao Li, Tian Weidong
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	sphingolipid bone remodeling osteoblast osteoclast S1P Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/ec6c9c78af704b0f9e1dbaac84989f38
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spelling	oai:doaj.org-article:ec6c9c78af704b0f9e1dbaac84989f382021-12-01T11:39:05ZThe Role of Sphingolipid Metabolism in Bone Remodeling2296-634X10.3389/fcell.2021.752540https://doaj.org/article/ec6c9c78af704b0f9e1dbaac84989f382021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.752540/fullhttps://doaj.org/toc/2296-634XEmerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obtain new insights into the role sphingolipid played on skeletal remodeling. This review summarizes studies or understandings of the crosstalk between sphingomyelin, ceramide, and sphingosine-1-phosphate (S1P) of sphingolipids family and the cells, especially osteoblasts and osteoclasts of the bone through which bone is remodeled during life constantly. This review also shows agonists and antagonists of S1P as possible therapeutic options and opportunities on bone diseases.Tang QiLiao LiTian WeidongFrontiers Media S.A.articlesphingolipidbone remodelingosteoblastosteoclastS1PBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sphingolipid bone remodeling osteoblast osteoclast S1P Biology (General) QH301-705.5
spellingShingle	sphingolipid bone remodeling osteoblast osteoclast S1P Biology (General) QH301-705.5 Tang Qi Liao Li Tian Weidong The Role of Sphingolipid Metabolism in Bone Remodeling
description	Emerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obtain new insights into the role sphingolipid played on skeletal remodeling. This review summarizes studies or understandings of the crosstalk between sphingomyelin, ceramide, and sphingosine-1-phosphate (S1P) of sphingolipids family and the cells, especially osteoblasts and osteoclasts of the bone through which bone is remodeled during life constantly. This review also shows agonists and antagonists of S1P as possible therapeutic options and opportunities on bone diseases.
format	article
author	Tang Qi Liao Li Tian Weidong
author_facet	Tang Qi Liao Li Tian Weidong
author_sort	Tang Qi
title	The Role of Sphingolipid Metabolism in Bone Remodeling
title_short	The Role of Sphingolipid Metabolism in Bone Remodeling
title_full	The Role of Sphingolipid Metabolism in Bone Remodeling
title_fullStr	The Role of Sphingolipid Metabolism in Bone Remodeling
title_full_unstemmed	The Role of Sphingolipid Metabolism in Bone Remodeling
title_sort	role of sphingolipid metabolism in bone remodeling
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ec6c9c78af704b0f9e1dbaac84989f38
work_keys_str_mv	AT tangqi theroleofsphingolipidmetabolisminboneremodeling AT liaoli theroleofsphingolipidmetabolisminboneremodeling AT tianweidong theroleofsphingolipidmetabolisminboneremodeling AT tangqi roleofsphingolipidmetabolisminboneremodeling AT liaoli roleofsphingolipidmetabolisminboneremodeling AT tianweidong roleofsphingolipidmetabolisminboneremodeling
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The Role of Sphingolipid Metabolism in Bone Remodeling

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