Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module

Adult neural stem cells are derived from an embryonic population of slowcycling progenitor cells, though how reduced cycling speed leads to establishment of the adult population has remained elusive. Here they show that non-oscillatory Notch-Hey signaling induced by slow-cycling contributes to long...

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Autores principales:	Yujin Harada, Mayumi Yamada, Itaru Imayoshi, Ryoichiro Kageyama, Yutaka Suzuki, Takaaki Kuniya, Shohei Furutachi, Daichi Kawaguchi, Yukiko Gotoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec6e527242f74785a99df676048fa5d1
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spelling	oai:doaj.org-article:ec6e527242f74785a99df676048fa5d12021-11-14T12:34:23ZCell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module10.1038/s41467-021-26605-02041-1723https://doaj.org/article/ec6e527242f74785a99df676048fa5d12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26605-0https://doaj.org/toc/2041-1723Adult neural stem cells are derived from an embryonic population of slowcycling progenitor cells, though how reduced cycling speed leads to establishment of the adult population has remained elusive. Here they show that non-oscillatory Notch-Hey signaling induced by slow-cycling contributes to long term maintenance of neural stem cells.Yujin HaradaMayumi YamadaItaru ImayoshiRyoichiro KageyamaYutaka SuzukiTakaaki KuniyaShohei FurutachiDaichi KawaguchiYukiko GotohNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yujin Harada Mayumi Yamada Itaru Imayoshi Ryoichiro Kageyama Yutaka Suzuki Takaaki Kuniya Shohei Furutachi Daichi Kawaguchi Yukiko Gotoh Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
description	Adult neural stem cells are derived from an embryonic population of slowcycling progenitor cells, though how reduced cycling speed leads to establishment of the adult population has remained elusive. Here they show that non-oscillatory Notch-Hey signaling induced by slow-cycling contributes to long term maintenance of neural stem cells.
format	article
author	Yujin Harada Mayumi Yamada Itaru Imayoshi Ryoichiro Kageyama Yutaka Suzuki Takaaki Kuniya Shohei Furutachi Daichi Kawaguchi Yukiko Gotoh
author_facet	Yujin Harada Mayumi Yamada Itaru Imayoshi Ryoichiro Kageyama Yutaka Suzuki Takaaki Kuniya Shohei Furutachi Daichi Kawaguchi Yukiko Gotoh
author_sort	Yujin Harada
title	Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
title_short	Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
title_full	Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
title_fullStr	Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
title_full_unstemmed	Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
title_sort	cell cycle arrest determines adult neural stem cell ontogeny by an embryonic notch-nonoscillatory hey1 module
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec6e527242f74785a99df676048fa5d1
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Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module

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