Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17

The pathogenic bacteriumLegionella pneumophila replicates within macrophages. Here, the authors show that L. pneumophilasecretes an effector protein that cleaves the host protein syntaxin 17, thus inhibiting autophagy and staurosporine-induced apoptosis in the host cell.

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Detalles Bibliográficos
Autores principales: Kohei Arasaki, Yumi Mikami, Stephanie R. Shames, Hiroki Inoue, Yuichi Wakana, Mitsuo Tagaya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
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Acceso en línea:https://doaj.org/article/ec754c6774e2435dac51a43ad70686a2
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Descripción
Sumario:The pathogenic bacteriumLegionella pneumophila replicates within macrophages. Here, the authors show that L. pneumophilasecretes an effector protein that cleaves the host protein syntaxin 17, thus inhibiting autophagy and staurosporine-induced apoptosis in the host cell.