Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17

The pathogenic bacteriumLegionella pneumophila replicates within macrophages. Here, the authors show that L. pneumophilasecretes an effector protein that cleaves the host protein syntaxin 17, thus inhibiting autophagy and staurosporine-induced apoptosis in the host cell.

Saved in:

Bibliographic Details
Main Authors:	Kohei Arasaki, Yumi Mikami, Stephanie R. Shames, Hiroki Inoue, Yuichi Wakana, Mitsuo Tagaya
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/ec754c6774e2435dac51a43ad70686a2
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:ec754c6774e2435dac51a43ad70686a2
record_format	dspace
spelling	oai:doaj.org-article:ec754c6774e2435dac51a43ad70686a22021-12-02T14:43:00ZLegionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 1710.1038/ncomms154062041-1723https://doaj.org/article/ec754c6774e2435dac51a43ad70686a22017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15406https://doaj.org/toc/2041-1723The pathogenic bacteriumLegionella pneumophila replicates within macrophages. Here, the authors show that L. pneumophilasecretes an effector protein that cleaves the host protein syntaxin 17, thus inhibiting autophagy and staurosporine-induced apoptosis in the host cell.Kohei ArasakiYumi MikamiStephanie R. ShamesHiroki InoueYuichi WakanaMitsuo TagayaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kohei Arasaki Yumi Mikami Stephanie R. Shames Hiroki Inoue Yuichi Wakana Mitsuo Tagaya Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17
description	The pathogenic bacteriumLegionella pneumophila replicates within macrophages. Here, the authors show that L. pneumophilasecretes an effector protein that cleaves the host protein syntaxin 17, thus inhibiting autophagy and staurosporine-induced apoptosis in the host cell.
format	article
author	Kohei Arasaki Yumi Mikami Stephanie R. Shames Hiroki Inoue Yuichi Wakana Mitsuo Tagaya
author_facet	Kohei Arasaki Yumi Mikami Stephanie R. Shames Hiroki Inoue Yuichi Wakana Mitsuo Tagaya
author_sort	Kohei Arasaki
title	Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17
title_short	Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17
title_full	Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17
title_fullStr	Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17
title_full_unstemmed	Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17
title_sort	legionella effector lpg1137 shuts down er-mitochondria communication through cleavage of syntaxin 17
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ec754c6774e2435dac51a43ad70686a2
work_keys_str_mv	AT koheiarasaki legionellaeffectorlpg1137shutsdownermitochondriacommunicationthroughcleavageofsyntaxin17 AT yumimikami legionellaeffectorlpg1137shutsdownermitochondriacommunicationthroughcleavageofsyntaxin17 AT stephaniershames legionellaeffectorlpg1137shutsdownermitochondriacommunicationthroughcleavageofsyntaxin17 AT hirokiinoue legionellaeffectorlpg1137shutsdownermitochondriacommunicationthroughcleavageofsyntaxin17 AT yuichiwakana legionellaeffectorlpg1137shutsdownermitochondriacommunicationthroughcleavageofsyntaxin17 AT mitsuotagaya legionellaeffectorlpg1137shutsdownermitochondriacommunicationthroughcleavageofsyntaxin17
_version_	1718389603969269760

Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17

Similar Items