Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review

Oral and craniofacial bone defects caused by congenital disease or trauma are widespread. In the case of severe alveolar bone defect, autologous bone grafting has been considered a “gold standard”; however, the procedure has several disadvantages, including limited supply, resorption, donor site mor...

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Autores principales:	Dušan Hollý, Martin Klein, Merita Mazreku, Radoslav Zamborský, Štefan Polák, Ľuboš Danišovič, Mária Csöbönyeiová
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	alveolar bone regeneration stem cell-based therapy tissue engineering exosomes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ec7727e29ecd4bbeb5c35e77f5125838
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spelling	oai:doaj.org-article:ec7727e29ecd4bbeb5c35e77f51258382021-11-11T17:12:05ZStem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review10.3390/ijms2221117461422-00671661-6596https://doaj.org/article/ec7727e29ecd4bbeb5c35e77f51258382021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11746https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Oral and craniofacial bone defects caused by congenital disease or trauma are widespread. In the case of severe alveolar bone defect, autologous bone grafting has been considered a “gold standard”; however, the procedure has several disadvantages, including limited supply, resorption, donor site morbidity, deformity, infection, and bone graft rejection. In the last few decades, bone tissue engineering combined with stem cell-based therapy may represent a possible alternative to current bone augmentation techniques. The number of studies investigating different cell-based bone tissue engineering methods to reconstruct alveolar bone damage is rapidly rising. As an interdisciplinary field, bone tissue engineering combines the use of osteogenic cells (stem cells/progenitor cells), bioactive molecules, and biocompatible scaffolds, whereas stem cells play a pivotal role. Therefore, our work highlights the osteogenic potential of various dental tissue-derived stem cells and induced pluripotent stem cells (iPSCs), the progress in differentiation techniques of iPSCs into osteoprogenitor cells, and the efforts that have been made to fabricate the most suitable and biocompatible scaffold material with osteoinductive properties for successful bone graft generation. Moreover, we discuss the application of stem cell-derived exosomes as a compelling new form of “stem-cell free” therapy.Dušan HollýMartin KleinMerita MazrekuRadoslav ZamborskýŠtefan PolákĽuboš DanišovičMária CsöbönyeiováMDPI AGarticlealveolar bone regenerationstem cell-based therapytissue engineeringexosomesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11746, p 11746 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alveolar bone regeneration stem cell-based therapy tissue engineering exosomes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	alveolar bone regeneration stem cell-based therapy tissue engineering exosomes Biology (General) QH301-705.5 Chemistry QD1-999 Dušan Hollý Martin Klein Merita Mazreku Radoslav Zamborský Štefan Polák Ľuboš Danišovič Mária Csöbönyeiová Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review
description	Oral and craniofacial bone defects caused by congenital disease or trauma are widespread. In the case of severe alveolar bone defect, autologous bone grafting has been considered a “gold standard”; however, the procedure has several disadvantages, including limited supply, resorption, donor site morbidity, deformity, infection, and bone graft rejection. In the last few decades, bone tissue engineering combined with stem cell-based therapy may represent a possible alternative to current bone augmentation techniques. The number of studies investigating different cell-based bone tissue engineering methods to reconstruct alveolar bone damage is rapidly rising. As an interdisciplinary field, bone tissue engineering combines the use of osteogenic cells (stem cells/progenitor cells), bioactive molecules, and biocompatible scaffolds, whereas stem cells play a pivotal role. Therefore, our work highlights the osteogenic potential of various dental tissue-derived stem cells and induced pluripotent stem cells (iPSCs), the progress in differentiation techniques of iPSCs into osteoprogenitor cells, and the efforts that have been made to fabricate the most suitable and biocompatible scaffold material with osteoinductive properties for successful bone graft generation. Moreover, we discuss the application of stem cell-derived exosomes as a compelling new form of “stem-cell free” therapy.
format	article
author	Dušan Hollý Martin Klein Merita Mazreku Radoslav Zamborský Štefan Polák Ľuboš Danišovič Mária Csöbönyeiová
author_facet	Dušan Hollý Martin Klein Merita Mazreku Radoslav Zamborský Štefan Polák Ľuboš Danišovič Mária Csöbönyeiová
author_sort	Dušan Hollý
title	Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review
title_short	Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review
title_full	Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review
title_fullStr	Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review
title_full_unstemmed	Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review
title_sort	stem cells and their derivatives—implications for alveolar bone regeneration: a comprehensive review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ec7727e29ecd4bbeb5c35e77f5125838
work_keys_str_mv	AT dusanholly stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview AT martinklein stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview AT meritamazreku stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview AT radoslavzamborsky stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview AT stefanpolak stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview AT lubosdanisovic stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview AT mariacsobonyeiova stemcellsandtheirderivativesimplicationsforalveolarboneregenerationacomprehensivereview
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Stem Cells and Their Derivatives—Implications for Alveolar Bone Regeneration: A Comprehensive Review

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