Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults

Abstract Many bariatric procedures are more effective for improving type-2 diabetes mellitus (T2DM) than conventional pharmacotherapy. The current research evaluated factors linked to complete and partial remission or improvement of T2DM after laparoscopic sleeve gastrectomy (LSG). The current prosp...

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Autores principales:	Ahmed Abdallah Salman, Mohamed Abdalla Salman, Mohamed A. Marie, Ahmed Rabiee, Mona Youssry Helmy, Mohamed Sabry Tourky, Mohamed Gamal Qassem, Hossam El-Din Shaaban, Mohamed D. Sarhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec796cac4c184a579df0434feed575cc
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spelling	oai:doaj.org-article:ec796cac4c184a579df0434feed575cc2021-12-02T17:05:12ZFactors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults10.1038/s41598-021-85450-92045-2322https://doaj.org/article/ec796cac4c184a579df0434feed575cc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85450-9https://doaj.org/toc/2045-2322Abstract Many bariatric procedures are more effective for improving type-2 diabetes mellitus (T2DM) than conventional pharmacotherapy. The current research evaluated factors linked to complete and partial remission or improvement of T2DM after laparoscopic sleeve gastrectomy (LSG). The current prospective study included all diabetic patients who were submitted LSG between January 2015 and June 2018 and completed a 2-year follow-up period. Patients were assessed at baseline and 2 years after LSG. This work comprised of 226 diabetic cases. Two years after LSG, 86 patients (38.1%) achieved complete remission of DM, and 24 (10.6%) reached partial remission. Only 14 patients (6.2%) showed no change in their diabetic status. On univariate analysis, age ≤ 45 years, duration of diabetes ≤ 5 years, use of a single oral antidiabetic, HbA1c ≤ 6.5%, HOMA-IR ≤ 4.6, C-peptide > 2.72 ng/mL, and BMI ≤ 40 kg/m2 predicted complete remission. The independent predictors of complete remission were age ≤ 45 years, duration of diabetes ≤ 5 years, use of a single oral antidiabetic, HOMA-IR ≤ 4.6, and C-peptide > 2.72 ng/mL. A combined marker of young age, short duration of DM, and low HOMA-IR predicted complete remission with sensitivity 93% and specificity 82%. Independent predictors of complete remission of T2DM after LSG were younger age, shorter duration, single oral antidiabetic, lower HOMA-IR, and higher C-peptide.Ahmed Abdallah SalmanMohamed Abdalla SalmanMohamed A. MarieAhmed RabieeMona Youssry HelmyMohamed Sabry TourkyMohamed Gamal QassemHossam El-Din ShaabanMohamed D. SarhanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ahmed Abdallah Salman Mohamed Abdalla Salman Mohamed A. Marie Ahmed Rabiee Mona Youssry Helmy Mohamed Sabry Tourky Mohamed Gamal Qassem Hossam El-Din Shaaban Mohamed D. Sarhan Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
description	Abstract Many bariatric procedures are more effective for improving type-2 diabetes mellitus (T2DM) than conventional pharmacotherapy. The current research evaluated factors linked to complete and partial remission or improvement of T2DM after laparoscopic sleeve gastrectomy (LSG). The current prospective study included all diabetic patients who were submitted LSG between January 2015 and June 2018 and completed a 2-year follow-up period. Patients were assessed at baseline and 2 years after LSG. This work comprised of 226 diabetic cases. Two years after LSG, 86 patients (38.1%) achieved complete remission of DM, and 24 (10.6%) reached partial remission. Only 14 patients (6.2%) showed no change in their diabetic status. On univariate analysis, age ≤ 45 years, duration of diabetes ≤ 5 years, use of a single oral antidiabetic, HbA1c ≤ 6.5%, HOMA-IR ≤ 4.6, C-peptide > 2.72 ng/mL, and BMI ≤ 40 kg/m2 predicted complete remission. The independent predictors of complete remission were age ≤ 45 years, duration of diabetes ≤ 5 years, use of a single oral antidiabetic, HOMA-IR ≤ 4.6, and C-peptide > 2.72 ng/mL. A combined marker of young age, short duration of DM, and low HOMA-IR predicted complete remission with sensitivity 93% and specificity 82%. Independent predictors of complete remission of T2DM after LSG were younger age, shorter duration, single oral antidiabetic, lower HOMA-IR, and higher C-peptide.
format	article
author	Ahmed Abdallah Salman Mohamed Abdalla Salman Mohamed A. Marie Ahmed Rabiee Mona Youssry Helmy Mohamed Sabry Tourky Mohamed Gamal Qassem Hossam El-Din Shaaban Mohamed D. Sarhan
author_facet	Ahmed Abdallah Salman Mohamed Abdalla Salman Mohamed A. Marie Ahmed Rabiee Mona Youssry Helmy Mohamed Sabry Tourky Mohamed Gamal Qassem Hossam El-Din Shaaban Mohamed D. Sarhan
author_sort	Ahmed Abdallah Salman
title	Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
title_short	Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
title_full	Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
title_fullStr	Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
title_full_unstemmed	Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
title_sort	factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec796cac4c184a579df0434feed575cc
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Factors associated with resolution of type-2 diabetes mellitus after sleeve gastrectomy in obese adults

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