Covalently-assembled single-chain protein nanostructures with ultra-high stability

De novo protein nanostructures are typically assembled via top-down approaches. Here, the authors developed a bottom-up approach, using split inteins to ligate multiple copies of a three-helix bundle to create 2D triangular and square-shaped structures with high stability.

Guardado en:

Detalles Bibliográficos
Autores principales:	Wenqin Bai, Cameron J. Sargent, Jeong-Mo Choi, Rohit V. Pappu, Fuzhong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec7cdad6dc2045c1b4932d232772c37b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec7cdad6dc2045c1b4932d232772c37b
record_format	dspace
spelling	oai:doaj.org-article:ec7cdad6dc2045c1b4932d232772c37b2021-12-02T14:39:38ZCovalently-assembled single-chain protein nanostructures with ultra-high stability10.1038/s41467-019-11285-82041-1723https://doaj.org/article/ec7cdad6dc2045c1b4932d232772c37b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11285-8https://doaj.org/toc/2041-1723De novo protein nanostructures are typically assembled via top-down approaches. Here, the authors developed a bottom-up approach, using split inteins to ligate multiple copies of a three-helix bundle to create 2D triangular and square-shaped structures with high stability.Wenqin BaiCameron J. SargentJeong-Mo ChoiRohit V. PappuFuzhong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenqin Bai Cameron J. Sargent Jeong-Mo Choi Rohit V. Pappu Fuzhong Zhang Covalently-assembled single-chain protein nanostructures with ultra-high stability
description	De novo protein nanostructures are typically assembled via top-down approaches. Here, the authors developed a bottom-up approach, using split inteins to ligate multiple copies of a three-helix bundle to create 2D triangular and square-shaped structures with high stability.
format	article
author	Wenqin Bai Cameron J. Sargent Jeong-Mo Choi Rohit V. Pappu Fuzhong Zhang
author_facet	Wenqin Bai Cameron J. Sargent Jeong-Mo Choi Rohit V. Pappu Fuzhong Zhang
author_sort	Wenqin Bai
title	Covalently-assembled single-chain protein nanostructures with ultra-high stability
title_short	Covalently-assembled single-chain protein nanostructures with ultra-high stability
title_full	Covalently-assembled single-chain protein nanostructures with ultra-high stability
title_fullStr	Covalently-assembled single-chain protein nanostructures with ultra-high stability
title_full_unstemmed	Covalently-assembled single-chain protein nanostructures with ultra-high stability
title_sort	covalently-assembled single-chain protein nanostructures with ultra-high stability
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ec7cdad6dc2045c1b4932d232772c37b
work_keys_str_mv	AT wenqinbai covalentlyassembledsinglechainproteinnanostructureswithultrahighstability AT cameronjsargent covalentlyassembledsinglechainproteinnanostructureswithultrahighstability AT jeongmochoi covalentlyassembledsinglechainproteinnanostructureswithultrahighstability AT rohitvpappu covalentlyassembledsinglechainproteinnanostructureswithultrahighstability AT fuzhongzhang covalentlyassembledsinglechainproteinnanostructureswithultrahighstability
_version_	1718390568701132800

Covalently-assembled single-chain protein nanostructures with ultra-high stability

Ejemplares similares