Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis

Abstract Tuberculosis (TB) is major health concern and reason of deaths from decades to current date. Even though with a lot of advancements, diagnostic techniques, and discovery of standard antibiotics TB remains crucial challenge and can create worst scenario for human health in near future. Nanop...

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Autores principales:	Chang Sun, Xiaoying Zhang, Jialu Wang, Yahao Chen, Cunren Meng
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Mesoporous silica nanoparticles Gold nanoparticles Tuberculosis Rapid diagnosis Calorimetric evaluation Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/ec7f57cb553a4371af42b4cefbf5fd27
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spelling	oai:doaj.org-article:ec7f57cb553a4371af42b4cefbf5fd272021-11-08T11:14:08ZNovel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis10.1186/s12906-021-03451-72662-7671https://doaj.org/article/ec7f57cb553a4371af42b4cefbf5fd272021-11-01T00:00:00Zhttps://doi.org/10.1186/s12906-021-03451-7https://doaj.org/toc/2662-7671Abstract Tuberculosis (TB) is major health concern and reason of deaths from decades to current date. Even though with a lot of advancements, diagnostic techniques, and discovery of standard antibiotics TB remains crucial challenge and can create worst scenario for human health in near future. Nanoparticles play emerging role in diagnosis and treatment of TB. In this study, we developed mesoporous silica nanoparticles containing gold (MSNs@GNPs) for rapid diagnosis and treatment of TB. The physicochemical characterization revealed effective surface morphology and particles diameter, that is applicable for in vitro applications. The in vitro antimicrobial analysis revealed that the designed MSNs@GNPs has retained significantly lower minimal inhibitory concentration (MIC) values and can effectively demolish mycobacterium tuberculosis (Mtb). Furthermore, the diagnosis efficiency of the MSNs@GNPs was evaluated by calorimetric analysis. Which demonstrates that MSNs@GNPs can be used for rapid diagnosis of the tuberculosis when applied on in vitro culture of the Mtb. The current study needs further verification on human’s clinical samples from tuberculosis patients. However, MSNs@GNPs can be a versatile clinical approach for the rapid diagnosis and clinical treatment of the tuberculosis.Chang SunXiaoying ZhangJialu WangYahao ChenCunren MengBMCarticleMesoporous silica nanoparticlesGold nanoparticlesTuberculosisRapid diagnosisCalorimetric evaluationOther systems of medicineRZ201-999ENBMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesoporous silica nanoparticles Gold nanoparticles Tuberculosis Rapid diagnosis Calorimetric evaluation Other systems of medicine RZ201-999
spellingShingle	Mesoporous silica nanoparticles Gold nanoparticles Tuberculosis Rapid diagnosis Calorimetric evaluation Other systems of medicine RZ201-999 Chang Sun Xiaoying Zhang Jialu Wang Yahao Chen Cunren Meng Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
description	Abstract Tuberculosis (TB) is major health concern and reason of deaths from decades to current date. Even though with a lot of advancements, diagnostic techniques, and discovery of standard antibiotics TB remains crucial challenge and can create worst scenario for human health in near future. Nanoparticles play emerging role in diagnosis and treatment of TB. In this study, we developed mesoporous silica nanoparticles containing gold (MSNs@GNPs) for rapid diagnosis and treatment of TB. The physicochemical characterization revealed effective surface morphology and particles diameter, that is applicable for in vitro applications. The in vitro antimicrobial analysis revealed that the designed MSNs@GNPs has retained significantly lower minimal inhibitory concentration (MIC) values and can effectively demolish mycobacterium tuberculosis (Mtb). Furthermore, the diagnosis efficiency of the MSNs@GNPs was evaluated by calorimetric analysis. Which demonstrates that MSNs@GNPs can be used for rapid diagnosis of the tuberculosis when applied on in vitro culture of the Mtb. The current study needs further verification on human’s clinical samples from tuberculosis patients. However, MSNs@GNPs can be a versatile clinical approach for the rapid diagnosis and clinical treatment of the tuberculosis.
format	article
author	Chang Sun Xiaoying Zhang Jialu Wang Yahao Chen Cunren Meng
author_facet	Chang Sun Xiaoying Zhang Jialu Wang Yahao Chen Cunren Meng
author_sort	Chang Sun
title	Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
title_short	Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
title_full	Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
title_fullStr	Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
title_full_unstemmed	Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
title_sort	novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ec7f57cb553a4371af42b4cefbf5fd27
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Novel mesoporous silica nanocarriers containing gold; a rapid diagnostic tool for tuberculosis

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