Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

Human α-synuclein overexpression in a mouse model of Parkinson’s disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

Abstract The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular alterations have been linked to neurodeg...

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Autores principales: Osama Elabi, Abderahim Gaceb, Robert Carlsson, Thomas Padel, Rana Soylu-Kucharz, Irene Cortijo, Wen Li, Jia-Yi Li, Gesine Paul
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/ec7f83bec5c641f586d67ee9ecc25ce2
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