Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses

Abstract A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration...

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Autores principales:	Sui-Yuan Chang, Kuo-Yen Huang, Tai-Ling Chao, Han-Chieh Kao, Yu-Hao Pang, Lin Lu, Chun-Lun Chiu, Hsin-Chang Huang, Ting-Jen Rachel Cheng, Jim-Min Fang, Pan-Chyr Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec8172096624498282192a2444a374c0
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spelling	oai:doaj.org-article:ec8172096624498282192a2444a374c02021-12-02T18:27:49ZNanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses10.1038/s41598-021-87254-32045-2322https://doaj.org/article/ec8172096624498282192a2444a374c02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87254-3https://doaj.org/toc/2045-2322Abstract A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 inhibited six major clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with effective concentration within the range to be used as food additives. TPNT1 was shown to block viral entry by inhibiting the binding of SARS-CoV-2 spike proteins to the angiotensin-converting enzyme 2 (ACE2) receptor and to interfere with the syncytium formation. In addition, TPNT1 also effectively reduced the cytopathic effects induced by human (H1N1) and avian (H5N1) influenza viruses, including the wild-type and oseltamivir-resistant virus isolates. Together with previously demonstrated efficacy as antimicrobials, TPNT1 can block viral entry and inhibit or prevent viral infection to provide prophylactic effects against both SARS-CoV-2 and opportunistic infections.Sui-Yuan ChangKuo-Yen HuangTai-Ling ChaoHan-Chieh KaoYu-Hao PangLin LuChun-Lun ChiuHsin-Chang HuangTing-Jen Rachel ChengJim-Min FangPan-Chyr YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sui-Yuan Chang Kuo-Yen Huang Tai-Ling Chao Han-Chieh Kao Yu-Hao Pang Lin Lu Chun-Lun Chiu Hsin-Chang Huang Ting-Jen Rachel Cheng Jim-Min Fang Pan-Chyr Yang Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses
description	Abstract A metal nanoparticle composite, namely TPNT1, which contains Au-NP (1 ppm), Ag-NP (5 ppm), ZnO-NP (60 ppm) and ClO2 (42.5 ppm) in aqueous solution was prepared and characterized by spectroscopy, transmission electron microscopy, dynamic light scattering analysis and potentiometric titration. Based on the in vitro cell-based assay, TPNT1 inhibited six major clades of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with effective concentration within the range to be used as food additives. TPNT1 was shown to block viral entry by inhibiting the binding of SARS-CoV-2 spike proteins to the angiotensin-converting enzyme 2 (ACE2) receptor and to interfere with the syncytium formation. In addition, TPNT1 also effectively reduced the cytopathic effects induced by human (H1N1) and avian (H5N1) influenza viruses, including the wild-type and oseltamivir-resistant virus isolates. Together with previously demonstrated efficacy as antimicrobials, TPNT1 can block viral entry and inhibit or prevent viral infection to provide prophylactic effects against both SARS-CoV-2 and opportunistic infections.
format	article
author	Sui-Yuan Chang Kuo-Yen Huang Tai-Ling Chao Han-Chieh Kao Yu-Hao Pang Lin Lu Chun-Lun Chiu Hsin-Chang Huang Ting-Jen Rachel Cheng Jim-Min Fang Pan-Chyr Yang
author_facet	Sui-Yuan Chang Kuo-Yen Huang Tai-Ling Chao Han-Chieh Kao Yu-Hao Pang Lin Lu Chun-Lun Chiu Hsin-Chang Huang Ting-Jen Rachel Cheng Jim-Min Fang Pan-Chyr Yang
author_sort	Sui-Yuan Chang
title	Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses
title_short	Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses
title_full	Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses
title_fullStr	Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses
title_full_unstemmed	Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses
title_sort	nanoparticle composite tpnt1 is effective against sars-cov-2 and influenza viruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec8172096624498282192a2444a374c0
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Nanoparticle composite TPNT1 is effective against SARS-CoV-2 and influenza viruses

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