Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.

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Detalles Bibliográficos
Autores principales: Jesus Cosin-Roger, Simona Simmen, Hassan Melhem, Kirstin Atrott, Isabelle Frey-Wagner, Martin Hausmann, Cheryl de Vallière, Marianne R. Spalinger, Patrick Spielmann, Roland H. Wenger, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Pedro A. Ruiz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/ec822dd8ef504b80b17abfefcd2b752a
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Descripción
Sumario:Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.

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