Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.

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Autores principales:	Jesus Cosin-Roger, Simona Simmen, Hassan Melhem, Kirstin Atrott, Isabelle Frey-Wagner, Martin Hausmann, Cheryl de Vallière, Marianne R. Spalinger, Patrick Spielmann, Roland H. Wenger, Jonas Zeitz, Stephan R. Vavricka, Gerhard Rogler, Pedro A. Ruiz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec822dd8ef504b80b17abfefcd2b752a
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spelling	oai:doaj.org-article:ec822dd8ef504b80b17abfefcd2b752a2021-12-02T13:23:47ZHypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation10.1038/s41467-017-00213-32041-1723https://doaj.org/article/ec822dd8ef504b80b17abfefcd2b752a2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00213-3https://doaj.org/toc/2041-1723Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.Jesus Cosin-RogerSimona SimmenHassan MelhemKirstin AtrottIsabelle Frey-WagnerMartin HausmannCheryl de VallièreMarianne R. SpalingerPatrick SpielmannRoland H. WengerJonas ZeitzStephan R. VavrickaGerhard RoglerPedro A. RuizNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jesus Cosin-Roger Simona Simmen Hassan Melhem Kirstin Atrott Isabelle Frey-Wagner Martin Hausmann Cheryl de Vallière Marianne R. Spalinger Patrick Spielmann Roland H. Wenger Jonas Zeitz Stephan R. Vavricka Gerhard Rogler Pedro A. Ruiz Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
description	Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.
format	article
author	Jesus Cosin-Roger Simona Simmen Hassan Melhem Kirstin Atrott Isabelle Frey-Wagner Martin Hausmann Cheryl de Vallière Marianne R. Spalinger Patrick Spielmann Roland H. Wenger Jonas Zeitz Stephan R. Vavricka Gerhard Rogler Pedro A. Ruiz
author_facet	Jesus Cosin-Roger Simona Simmen Hassan Melhem Kirstin Atrott Isabelle Frey-Wagner Martin Hausmann Cheryl de Vallière Marianne R. Spalinger Patrick Spielmann Roland H. Wenger Jonas Zeitz Stephan R. Vavricka Gerhard Rogler Pedro A. Ruiz
author_sort	Jesus Cosin-Roger
title	Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
title_short	Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
title_full	Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
title_fullStr	Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
title_full_unstemmed	Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
title_sort	hypoxia ameliorates intestinal inflammation through nlrp3/mtor downregulation and autophagy activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ec822dd8ef504b80b17abfefcd2b752a
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_version_	1718393186809806848

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

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