Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that berberine can promote insulin secretion in health...

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Autores principales:	Miao-Miao Zhao, Jing Lu, Sen Li, Hao Wang, Xi Cao, Qi Li, Ting-Ting Shi, Kohichi Matsunaga, Chen Chen, Haixia Huang, Testuro Izumi, Jin-Kui Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec84125247fe45d184dfac34b2787232
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spelling	oai:doaj.org-article:ec84125247fe45d184dfac34b27872322021-12-02T17:27:04ZBerberine is an insulin secretagogue targeting the KCNH6 potassium channel10.1038/s41467-021-25952-22041-1723https://doaj.org/article/ec84125247fe45d184dfac34b27872322021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25952-2https://doaj.org/toc/2041-1723Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that berberine can promote insulin secretion in healthy men in a phase 1 clinical trial.Miao-Miao ZhaoJing LuSen LiHao WangXi CaoQi LiTing-Ting ShiKohichi MatsunagaChen ChenHaixia HuangTesturo IzumiJin-Kui YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miao-Miao Zhao Jing Lu Sen Li Hao Wang Xi Cao Qi Li Ting-Ting Shi Kohichi Matsunaga Chen Chen Haixia Huang Testuro Izumi Jin-Kui Yang Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
description	Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that berberine can promote insulin secretion in healthy men in a phase 1 clinical trial.
format	article
author	Miao-Miao Zhao Jing Lu Sen Li Hao Wang Xi Cao Qi Li Ting-Ting Shi Kohichi Matsunaga Chen Chen Haixia Huang Testuro Izumi Jin-Kui Yang
author_facet	Miao-Miao Zhao Jing Lu Sen Li Hao Wang Xi Cao Qi Li Ting-Ting Shi Kohichi Matsunaga Chen Chen Haixia Huang Testuro Izumi Jin-Kui Yang
author_sort	Miao-Miao Zhao
title	Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
title_short	Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
title_full	Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
title_fullStr	Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
title_full_unstemmed	Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
title_sort	berberine is an insulin secretagogue targeting the kcnh6 potassium channel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec84125247fe45d184dfac34b2787232
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Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

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