Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery

Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery

Johant Lakey-Beitia,1,2 Deborah Doens,2,3 D Jagadeesh Kumar,4 Enrique Murillo,5 Patricia L Fernandez,3 KS Rao,6 Armando A Durant-Archibold1,5 1Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), P...

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Autores principales: Lakey-Beitia J, Doens D, Jagadeesh Kumar D, Murillo E, Fernández PL, Rao KS, Durant-Archibold AA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Alzheimer’s disease
aging
antiamyloidogenic activity
cryptocapsin
cryptocapsin-5
6-epoxide
zeaxanthin.
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/ec84f006976148e7b3fe827036f8a7fb
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spelling oai:doaj.org-article:ec84f006976148e7b3fe827036f8a7fb2021-12-02T08:41:41ZAnti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery1178-1998https://doaj.org/article/ec84f006976148e7b3fe827036f8a7fb2017-05-01T00:00:00Zhttps://www.dovepress.com/anti-amyloid-aggregation-activity-of-novel-carotenoids-implications-fo-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Johant Lakey-Beitia,1,2 Deborah Doens,2,3 D Jagadeesh Kumar,4 Enrique Murillo,5 Patricia L Fernandez,3 KS Rao,6 Armando A Durant-Archibold1,5 1Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama; 2Department of Biotechnology, Acharya Nagarjuna University, Guntur, India; 3Center for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama; 4Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Bangalore, India; 5Department of Biochemistry, College of Natural, Exact Sciences and Technology, University of Panama, Panama, Republic of Panama; 6Center for Neuroscience, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama Abstract: Alzheimer’s disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals present mainly in fruits and vegetables with reported benefits for human health. In this research, the anti-amyloidogenic activity of three carotenoids, cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin, was assessed. Cryptocapsin showed the highest bioactivity, while cryptocapsin-5,6-epoxide and zeaxanthin exhibited similar activity on anti-aggregation assays. Molecular modeling analysis revealed that the evaluated carotenoids might follow two mechanisms for inhibiting Aβ aggregation: by preventing the formation of the fibril and through disruption of the Aβ aggregates. Our studies provided evidence that cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin have anti-amyloidogenic potential and could be used for prevention and treatment of AD. Keywords: Alzheimer’s disease, aging, anti-amyloidogenic activity, cryptocapsin, cryptocapsin-5,6-epoxide, zeaxanthinLakey-Beitia JDoens DJagadeesh Kumar DMurillo EFernández PLRao KSDurant-Archibold AADove Medical PressarticleAlzheimer’s diseaseagingantiamyloidogenic activitycryptocapsincryptocapsin-56-epoxidezeaxanthin.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 815-822 (2017)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer’s disease
aging
antiamyloidogenic activity
cryptocapsin
cryptocapsin-5
6-epoxide
zeaxanthin.
Geriatrics
RC952-954.6
spellingShingle Alzheimer’s disease
aging
antiamyloidogenic activity
cryptocapsin
cryptocapsin-5
6-epoxide
zeaxanthin.
Geriatrics
RC952-954.6
Lakey-Beitia J
Doens D
Jagadeesh Kumar D
Murillo E
Fernández PL
Rao KS
Durant-Archibold AA
Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
description Johant Lakey-Beitia,1,2 Deborah Doens,2,3 D Jagadeesh Kumar,4 Enrique Murillo,5 Patricia L Fernandez,3 KS Rao,6 Armando A Durant-Archibold1,5 1Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama; 2Department of Biotechnology, Acharya Nagarjuna University, Guntur, India; 3Center for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama; 4Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Bangalore, India; 5Department of Biochemistry, College of Natural, Exact Sciences and Technology, University of Panama, Panama, Republic of Panama; 6Center for Neuroscience, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama Abstract: Alzheimer’s disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals present mainly in fruits and vegetables with reported benefits for human health. In this research, the anti-amyloidogenic activity of three carotenoids, cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin, was assessed. Cryptocapsin showed the highest bioactivity, while cryptocapsin-5,6-epoxide and zeaxanthin exhibited similar activity on anti-aggregation assays. Molecular modeling analysis revealed that the evaluated carotenoids might follow two mechanisms for inhibiting Aβ aggregation: by preventing the formation of the fibril and through disruption of the Aβ aggregates. Our studies provided evidence that cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin have anti-amyloidogenic potential and could be used for prevention and treatment of AD. Keywords: Alzheimer’s disease, aging, anti-amyloidogenic activity, cryptocapsin, cryptocapsin-5,6-epoxide, zeaxanthin
format article
author Lakey-Beitia J
Doens D
Jagadeesh Kumar D
Murillo E
Fernández PL
Rao KS
Durant-Archibold AA
author_facet Lakey-Beitia J
Doens D
Jagadeesh Kumar D
Murillo E
Fernández PL
Rao KS
Durant-Archibold AA
author_sort Lakey-Beitia J
title Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
title_short Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
title_full Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
title_fullStr Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
title_full_unstemmed Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
title_sort anti-amyloid aggregation activity of novel carotenoids: implications for alzheimer’s drug discovery
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/ec84f006976148e7b3fe827036f8a7fb
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