The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
Abstract Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we re...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ec866784239c40d8b7031906e2ca7586 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:ec866784239c40d8b7031906e2ca7586 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:ec866784239c40d8b7031906e2ca75862021-12-02T14:02:53ZThe effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization10.1038/s41541-021-00313-82059-0105https://doaj.org/article/ec866784239c40d8b7031906e2ca75862021-03-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00313-8https://doaj.org/toc/2059-0105Abstract Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7–2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.Jing ZouXuping XieCamila R. Fontes-GarfiasKena A. SwansonIsis KanevskyKristin TompkinsMark CutlerDavid CooperPhilip R. DormitzerPei-Yong ShiNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-4 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jing Zou Xuping Xie Camila R. Fontes-Garfias Kena A. Swanson Isis Kanevsky Kristin Tompkins Mark Cutler David Cooper Philip R. Dormitzer Pei-Yong Shi The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization |
| description |
Abstract Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7–2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial. |
| format |
article |
| author |
Jing Zou Xuping Xie Camila R. Fontes-Garfias Kena A. Swanson Isis Kanevsky Kristin Tompkins Mark Cutler David Cooper Philip R. Dormitzer Pei-Yong Shi |
| author_facet |
Jing Zou Xuping Xie Camila R. Fontes-Garfias Kena A. Swanson Isis Kanevsky Kristin Tompkins Mark Cutler David Cooper Philip R. Dormitzer Pei-Yong Shi |
| author_sort |
Jing Zou |
| title |
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization |
| title_short |
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization |
| title_full |
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization |
| title_fullStr |
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization |
| title_full_unstemmed |
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization |
| title_sort |
effect of sars-cov-2 d614g mutation on bnt162b2 vaccine-elicited neutralization |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ec866784239c40d8b7031906e2ca7586 |
| work_keys_str_mv |
AT jingzou theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT xupingxie theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT camilarfontesgarfias theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT kenaaswanson theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT isiskanevsky theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT kristintompkins theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT markcutler theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT davidcooper theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT philiprdormitzer theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT peiyongshi theeffectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT jingzou effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT xupingxie effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT camilarfontesgarfias effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT kenaaswanson effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT isiskanevsky effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT kristintompkins effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT markcutler effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT davidcooper effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT philiprdormitzer effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization AT peiyongshi effectofsarscov2d614gmutationonbnt162b2vaccineelicitedneutralization |
| _version_ |
1718392116170719232 |