CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

CAR-T cell therapy targeting CD19 is not as efficient to treat lymphoma with nodal dissemination as it is for B cell leukaemia. Here, the authors generate CAR-T cells against CXCR5 and show they inhibit tumour growth by depleting both B and follicular T helper cells in lymphoma models.

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Autores principales: Mario Bunse, Janina Pfeilschifter, Julia Bluhm, Maria Zschummel, Jara J. Joedicke, Anthea Wirges, Helen Stark, Vivien Kretschmer, Markus Chmielewski, Wolfgang Uckert, Hinrich Abken, Jörg Westermann, Armin Rehm, Uta E. Höpken
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/ec898a29a91e4a4fa35537b32be47016
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spelling oai:doaj.org-article:ec898a29a91e4a4fa35537b32be470162021-12-02T14:11:57ZCXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells10.1038/s41467-020-20488-32041-1723https://doaj.org/article/ec898a29a91e4a4fa35537b32be470162021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20488-3https://doaj.org/toc/2041-1723CAR-T cell therapy targeting CD19 is not as efficient to treat lymphoma with nodal dissemination as it is for B cell leukaemia. Here, the authors generate CAR-T cells against CXCR5 and show they inhibit tumour growth by depleting both B and follicular T helper cells in lymphoma models.Mario BunseJanina PfeilschifterJulia BluhmMaria ZschummelJara J. JoedickeAnthea WirgesHelen StarkVivien KretschmerMarkus ChmielewskiWolfgang UckertHinrich AbkenJörg WestermannArmin RehmUta E. HöpkenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mario Bunse
Janina Pfeilschifter
Julia Bluhm
Maria Zschummel
Jara J. Joedicke
Anthea Wirges
Helen Stark
Vivien Kretschmer
Markus Chmielewski
Wolfgang Uckert
Hinrich Abken
Jörg Westermann
Armin Rehm
Uta E. Höpken
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
description CAR-T cell therapy targeting CD19 is not as efficient to treat lymphoma with nodal dissemination as it is for B cell leukaemia. Here, the authors generate CAR-T cells against CXCR5 and show they inhibit tumour growth by depleting both B and follicular T helper cells in lymphoma models.
format article
author Mario Bunse
Janina Pfeilschifter
Julia Bluhm
Maria Zschummel
Jara J. Joedicke
Anthea Wirges
Helen Stark
Vivien Kretschmer
Markus Chmielewski
Wolfgang Uckert
Hinrich Abken
Jörg Westermann
Armin Rehm
Uta E. Höpken
author_facet Mario Bunse
Janina Pfeilschifter
Julia Bluhm
Maria Zschummel
Jara J. Joedicke
Anthea Wirges
Helen Stark
Vivien Kretschmer
Markus Chmielewski
Wolfgang Uckert
Hinrich Abken
Jörg Westermann
Armin Rehm
Uta E. Höpken
author_sort Mario Bunse
title CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
title_short CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
title_full CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
title_fullStr CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
title_full_unstemmed CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells
title_sort cxcr5 car-t cells simultaneously target b cell non-hodgkin’s lymphoma and tumor-supportive follicular t helper cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ec898a29a91e4a4fa35537b32be47016
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