Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats

Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies of pregnancy. The cardiovascular consequences of IUGR do not disappear in adulthood and can manifest themselves in pathological alterations of vasomotor control. The hypothesis was tested that IUGR weakens anticont...

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Autores principales:	Ekaterina K. Selivanova, Anastasia A. Shvetsova, Lyubov D. Shilova, Olga S. Tarasova, Dina K. Gaynullina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec8a4cecac524e82a75e3c827b90701d
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spelling	oai:doaj.org-article:ec8a4cecac524e82a75e3c827b90701d2021-12-02T18:30:45ZIntrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats10.1038/s41598-021-93491-32045-2322https://doaj.org/article/ec8a4cecac524e82a75e3c827b90701d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93491-3https://doaj.org/toc/2045-2322Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies of pregnancy. The cardiovascular consequences of IUGR do not disappear in adulthood and can manifest themselves in pathological alterations of vasomotor control. The hypothesis was tested that IUGR weakens anticontractile influence of NO and augments procontractile influence of Rho-kinase in arteries of adult offspring. To model IUGR in the rat, dams were 50% food restricted starting from the gestational day 11 till delivery. Mesenteric and coronary arteries of male offspring were studied at the age of 3 months using wire myography, qPCR, and Western blotting. Contractile responses of mesenteric arteries to α1-adrenoceptor agonist methoxamine as well as influences of NO and Rho-kinase did not differ between control and IUGR rats. However, coronary arteries of IUGR rats demonstrated elevated contraction to thromboxane A2 receptor agonist U46619 due to weakened anticontractile influence of NO and enhanced role of Rho-kinase in the endothelium. This was accompanied by reduced abundance of SODI protein and elevated content of RhoA protein in coronary arteries of IUGR rats. IUGR considerably changes the regulation of coronary vascular tone in adulthood and, therefore, can serve as a risk factor for the development of cardiac disorders.Ekaterina K. SelivanovaAnastasia A. ShvetsovaLyubov D. ShilovaOlga S. TarasovaDina K. GaynullinaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ekaterina K. Selivanova Anastasia A. Shvetsova Lyubov D. Shilova Olga S. Tarasova Dina K. Gaynullina Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats
description	Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies of pregnancy. The cardiovascular consequences of IUGR do not disappear in adulthood and can manifest themselves in pathological alterations of vasomotor control. The hypothesis was tested that IUGR weakens anticontractile influence of NO and augments procontractile influence of Rho-kinase in arteries of adult offspring. To model IUGR in the rat, dams were 50% food restricted starting from the gestational day 11 till delivery. Mesenteric and coronary arteries of male offspring were studied at the age of 3 months using wire myography, qPCR, and Western blotting. Contractile responses of mesenteric arteries to α1-adrenoceptor agonist methoxamine as well as influences of NO and Rho-kinase did not differ between control and IUGR rats. However, coronary arteries of IUGR rats demonstrated elevated contraction to thromboxane A2 receptor agonist U46619 due to weakened anticontractile influence of NO and enhanced role of Rho-kinase in the endothelium. This was accompanied by reduced abundance of SODI protein and elevated content of RhoA protein in coronary arteries of IUGR rats. IUGR considerably changes the regulation of coronary vascular tone in adulthood and, therefore, can serve as a risk factor for the development of cardiac disorders.
format	article
author	Ekaterina K. Selivanova Anastasia A. Shvetsova Lyubov D. Shilova Olga S. Tarasova Dina K. Gaynullina
author_facet	Ekaterina K. Selivanova Anastasia A. Shvetsova Lyubov D. Shilova Olga S. Tarasova Dina K. Gaynullina
author_sort	Ekaterina K. Selivanova
title	Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats
title_short	Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats
title_full	Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats
title_fullStr	Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats
title_full_unstemmed	Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats
title_sort	intrauterine growth restriction weakens anticontractile influence of no in coronary arteries of adult rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec8a4cecac524e82a75e3c827b90701d
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Intrauterine﻿ growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats

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Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats