Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

Hair loss: The protein that signals regeneration Signals from a protein that regulates cell division are essential to maintain the stem cells that regenerate hair follicles. Jeff Biernaskie and colleagues at Canada’s University of Calgary found signals from platelet-derived growth factor (PDGF) prom...

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Autores principales:	Raquel González, Garrett Moffatt, Andrew Hagner, Sarthak Sinha, Wisoo Shin, Waleed Rahmani, Andrew Chojnacki, Jeff Biernaskie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/ec900d3573be472f85b9707751458f4d
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spelling	oai:doaj.org-article:ec900d3573be472f85b9707751458f4d2021-12-02T16:05:45ZPlatelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal10.1038/s41536-017-0013-42057-3995https://doaj.org/article/ec900d3573be472f85b9707751458f4d2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0013-4https://doaj.org/toc/2057-3995Hair loss: The protein that signals regeneration Signals from a protein that regulates cell division are essential to maintain the stem cells that regenerate hair follicles. Jeff Biernaskie and colleagues at Canada’s University of Calgary found signals from platelet-derived growth factor (PDGF) promote self-renewal of ‘hair follicle dermal stem cells’ (hfDSCs)—cells present at the bottom of hair follicles important for their regeneration. They ‘turned off’ the gene responsible for PDGF production in hfDSCs in mice. This led to a significant reduction in the stem cells with successive hair cycles. They also tested the effects of PDGF signaling molecules on isolated hfDSCs and found they improved their ability to proliferate and to induce follicle regeneration. The results suggest disruption to PDGF signaling may contribute to hair loss. PDGF could be an important additive to rapidly expand hfDSCs ex vivo for cell-based therapies.Raquel GonzálezGarrett MoffattAndrew HagnerSarthak SinhaWisoo ShinWaleed RahmaniAndrew ChojnackiJeff BiernaskieNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Raquel González Garrett Moffatt Andrew Hagner Sarthak Sinha Wisoo Shin Waleed Rahmani Andrew Chojnacki Jeff Biernaskie Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
description	Hair loss: The protein that signals regeneration Signals from a protein that regulates cell division are essential to maintain the stem cells that regenerate hair follicles. Jeff Biernaskie and colleagues at Canada’s University of Calgary found signals from platelet-derived growth factor (PDGF) promote self-renewal of ‘hair follicle dermal stem cells’ (hfDSCs)—cells present at the bottom of hair follicles important for their regeneration. They ‘turned off’ the gene responsible for PDGF production in hfDSCs in mice. This led to a significant reduction in the stem cells with successive hair cycles. They also tested the effects of PDGF signaling molecules on isolated hfDSCs and found they improved their ability to proliferate and to induce follicle regeneration. The results suggest disruption to PDGF signaling may contribute to hair loss. PDGF could be an important additive to rapidly expand hfDSCs ex vivo for cell-based therapies.
format	article
author	Raquel González Garrett Moffatt Andrew Hagner Sarthak Sinha Wisoo Shin Waleed Rahmani Andrew Chojnacki Jeff Biernaskie
author_facet	Raquel González Garrett Moffatt Andrew Hagner Sarthak Sinha Wisoo Shin Waleed Rahmani Andrew Chojnacki Jeff Biernaskie
author_sort	Raquel González
title	Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
title_short	Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
title_full	Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
title_fullStr	Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
title_full_unstemmed	Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
title_sort	platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ec900d3573be472f85b9707751458f4d
work_keys_str_mv	AT raquelgonzalez plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT garrettmoffatt plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT andrewhagner plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT sarthaksinha plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT wisooshin plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT waleedrahmani plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT andrewchojnacki plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal AT jeffbiernaskie plateletderivedgrowthfactorsignalingmodulatesadulthairfollicledermalstemcellmaintenanceandselfrenewal
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Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

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