Inducible Nitric Oxide Synthase Is a Key Host Factor for <italic toggle="yes">Toxoplasma</italic> GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response

Inducible Nitric Oxide Synthase Is a Key Host Factor for <italic toggle="yes">Toxoplasma</italic> GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response

ABSTRACT Although Toxoplasma virulence mechanisms targeting gamma interferon (IFN-γ)-induced cell-autonomous antiparasitic immunity have been extensively characterized in mice, the virulence mechanisms in humans remain uncertain, partly because cell-autonomous immune responses against Toxoplasma dif...

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Autores principales: Hironori Bando, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ji Su Ma, Shun Tanaka, Yihong Cai, Jianfa Liu, Jilong Shen, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
Toxoplasma gondii
cell-autonomous immunity
host-parasite interaction
human immunology
immune suppression
interferon
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/ec961779ed0048a0a5ad9672f2d25f84
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