Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections

Abstract Toll-like receptors (TLRs) control anti-viral responses both directly in infected cells and in responding cells of the immune systems. Therefore, they are crucial for responses against the oncogenic γ-herpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus and the relat...

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Autor principal:	Marta Maria Gaglia
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Toll-like receptors KSHV HHV-8 EBV MHV68 Gammaherpesvirus Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ec98aef0b0eb452b86f3983e9cb21ca8
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spelling	oai:doaj.org-article:ec98aef0b0eb452b86f3983e9cb21ca82021-11-14T12:02:04ZAnti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections10.1186/s12985-021-01678-x1743-422Xhttps://doaj.org/article/ec98aef0b0eb452b86f3983e9cb21ca82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12985-021-01678-xhttps://doaj.org/toc/1743-422XAbstract Toll-like receptors (TLRs) control anti-viral responses both directly in infected cells and in responding cells of the immune systems. Therefore, they are crucial for responses against the oncogenic γ-herpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus and the related murine virus MHV68, which directly infect immune system cells. However, since these viruses also cause lifelong persistent infections, TLRs may also be involved in modulation of inflammation during latent infection and contribute to virus-driven tumorigenesis. This review summarizes work on both of these aspects of TLR/γ-herpesvirus interactions, as well as results showing that TLR activity can drive these viruses’ re-entry into the replicative lytic cycle.Marta Maria GagliaBMCarticleToll-like receptorsKSHVHHV-8EBVMHV68GammaherpesvirusInfectious and parasitic diseasesRC109-216ENVirology Journal, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Toll-like receptors KSHV HHV-8 EBV MHV68 Gammaherpesvirus Infectious and parasitic diseases RC109-216
spellingShingle	Toll-like receptors KSHV HHV-8 EBV MHV68 Gammaherpesvirus Infectious and parasitic diseases RC109-216 Marta Maria Gaglia Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
description	Abstract Toll-like receptors (TLRs) control anti-viral responses both directly in infected cells and in responding cells of the immune systems. Therefore, they are crucial for responses against the oncogenic γ-herpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus and the related murine virus MHV68, which directly infect immune system cells. However, since these viruses also cause lifelong persistent infections, TLRs may also be involved in modulation of inflammation during latent infection and contribute to virus-driven tumorigenesis. This review summarizes work on both of these aspects of TLR/γ-herpesvirus interactions, as well as results showing that TLR activity can drive these viruses’ re-entry into the replicative lytic cycle.
format	article
author	Marta Maria Gaglia
author_facet	Marta Maria Gaglia
author_sort	Marta Maria Gaglia
title	Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
title_short	Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
title_full	Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
title_fullStr	Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
title_full_unstemmed	Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections
title_sort	anti-viral and pro-inflammatory functions of toll-like receptors during gamma-herpesvirus infections
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ec98aef0b0eb452b86f3983e9cb21ca8
work_keys_str_mv	AT martamariagaglia antiviralandproinflammatoryfunctionsoftolllikereceptorsduringgammaherpesvirusinfections
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Anti-viral and pro-inflammatory functions of Toll-like receptors during gamma-herpesvirus infections

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