TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition o...

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Autores principales:	Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec9909b7b0774e2691625135a2850ac1
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spelling	oai:doaj.org-article:ec9909b7b0774e2691625135a2850ac12021-12-02T17:37:14ZTASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control10.1038/s41467-020-18761-62041-1723https://doaj.org/article/ec9909b7b0774e2691625135a2850ac12020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18761-6https://doaj.org/toc/2041-1723The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition over targets genome wide.Christopher H. DouseIva A. TchasovnikarovaRichard T. TimmsAnna V. ProtasioMarta SeczynskaDaniil M. PrigozhinAnna AlbeckaJane WagstaffJames C. WilliamsonStefan M. V. FreundPaul J. LehnerYorgo ModisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher H. Douse Iva A. Tchasovnikarova Richard T. Timms Anna V. Protasio Marta Seczynska Daniil M. Prigozhin Anna Albecka Jane Wagstaff James C. Williamson Stefan M. V. Freund Paul J. Lehner Yorgo Modis TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
description	The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-dependent transgene repression and H3K9me3 deposition over targets genome wide.
format	article
author	Christopher H. Douse Iva A. Tchasovnikarova Richard T. Timms Anna V. Protasio Marta Seczynska Daniil M. Prigozhin Anna Albecka Jane Wagstaff James C. Williamson Stefan M. V. Freund Paul J. Lehner Yorgo Modis
author_facet	Christopher H. Douse Iva A. Tchasovnikarova Richard T. Timms Anna V. Protasio Marta Seczynska Daniil M. Prigozhin Anna Albecka Jane Wagstaff James C. Williamson Stefan M. V. Freund Paul J. Lehner Yorgo Modis
author_sort	Christopher H. Douse
title	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_short	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_full	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_fullStr	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_full_unstemmed	TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
title_sort	tasor is a pseudo-parp that directs hush complex assembly and epigenetic transposon control
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ec9909b7b0774e2691625135a2850ac1
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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

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