Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata

Hongru Zhang,1 Joe Antony Jacob,2 Ziyu Jiang,3 Senlei Xu,1 Ke Sun,1 Zehao Zhong,1 Nithya Varadharaju,4 Achiraman Shanmugam21The Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People’s Republic of China; 2Department of Environmental Biotec...

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Autores principales:	Zhang H, Jacob JA, Jiang Z, Xu S, Sun K, Zhong Z, Varadharaju N, Shanmugam A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Mangroves Rhizophora apiculata silver nanoparticles carbon tetrachloride hepatotoxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ec99a255bdab4154b337980ad431fc7c
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spelling	oai:doaj.org-article:ec99a255bdab4154b337980ad431fc7c2021-12-02T04:45:03ZHepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata1178-2013https://doaj.org/article/ec99a255bdab4154b337980ad431fc7c2019-05-01T00:00:00Zhttps://www.dovepress.com/hepatoprotective-effect-of-silver-nanoparticles-synthesized-using-aque-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hongru Zhang,1 Joe Antony Jacob,2 Ziyu Jiang,3 Senlei Xu,1 Ke Sun,1 Zehao Zhong,1 Nithya Varadharaju,4 Achiraman Shanmugam21The Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People’s Republic of China; 2Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India; 3Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, People’s Republic of China; 4Department of Animal Health and Management, Alagappa University, Karaikudi 630 003, Tamil Nadu, IndiaBackground: Liver plays a vital role in the elimination of xenobiotics that can induce hepatotoxicity in living organisms.Silver nanoparticles have evolved recently as an alternative in various industries and are used for their biomedical applications.Rhizophora apiculata is a least studied mangrove-based plant that has been used in the traditional medicine of Southeast Asia for its healing properties. It is a well-known fact that the generation of free radicals has been associated with oxidative stress. Methods: Hence, in this study we used carbon tetrachloride as a hepatotoxin to induce liver damage. The protective effects of silver nanoparticles synthesized using Rhizophora apiculata on hepatotoxin-induced liver damage in experimental mice were assessed. Results: The results of the assessment indicate that silver nanoparticles were effective in protecting the liver from damages induced by carbon tetrachloride. Conclusion: Among existing literature, this is the first ever approach for hepatoprotective effect of nanoparticles derived using plant extract from mangrove ecosystem.Keywords: mangroves, Rhizophora apiculata, silver nanoparticles, carbon tetrachloride, hepatotoxicityZhang HJacob JAJiang ZXu SSun KZhong ZVaradharaju NShanmugam ADove Medical PressarticleMangrovesRhizophora apiculatasilver nanoparticlescarbon tetrachloridehepatotoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3517-3524 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mangroves Rhizophora apiculata silver nanoparticles carbon tetrachloride hepatotoxicity Medicine (General) R5-920
spellingShingle	Mangroves Rhizophora apiculata silver nanoparticles carbon tetrachloride hepatotoxicity Medicine (General) R5-920 Zhang H Jacob JA Jiang Z Xu S Sun K Zhong Z Varadharaju N Shanmugam A Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
description	Hongru Zhang,1 Joe Antony Jacob,2 Ziyu Jiang,3 Senlei Xu,1 Ke Sun,1 Zehao Zhong,1 Nithya Varadharaju,4 Achiraman Shanmugam21The Second Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People’s Republic of China; 2Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, 620024, Tamil Nadu, India; 3Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, People’s Republic of China; 4Department of Animal Health and Management, Alagappa University, Karaikudi 630 003, Tamil Nadu, IndiaBackground: Liver plays a vital role in the elimination of xenobiotics that can induce hepatotoxicity in living organisms.Silver nanoparticles have evolved recently as an alternative in various industries and are used for their biomedical applications.Rhizophora apiculata is a least studied mangrove-based plant that has been used in the traditional medicine of Southeast Asia for its healing properties. It is a well-known fact that the generation of free radicals has been associated with oxidative stress. Methods: Hence, in this study we used carbon tetrachloride as a hepatotoxin to induce liver damage. The protective effects of silver nanoparticles synthesized using Rhizophora apiculata on hepatotoxin-induced liver damage in experimental mice were assessed. Results: The results of the assessment indicate that silver nanoparticles were effective in protecting the liver from damages induced by carbon tetrachloride. Conclusion: Among existing literature, this is the first ever approach for hepatoprotective effect of nanoparticles derived using plant extract from mangrove ecosystem.Keywords: mangroves, Rhizophora apiculata, silver nanoparticles, carbon tetrachloride, hepatotoxicity
format	article
author	Zhang H Jacob JA Jiang Z Xu S Sun K Zhong Z Varadharaju N Shanmugam A
author_facet	Zhang H Jacob JA Jiang Z Xu S Sun K Zhong Z Varadharaju N Shanmugam A
author_sort	Zhang H
title	Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
title_short	Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
title_full	Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
title_fullStr	Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
title_full_unstemmed	Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
title_sort	hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of rhizophora apiculata
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ec99a255bdab4154b337980ad431fc7c
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Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata

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