Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning

Abstract Learning to anticipate potentially dangerous contexts is an adaptive behavioral response to coping with stressors. An animal’s stress coping style (e.g. proactive–reactive axis) is known to influence how it encodes salient events. However, the neural and molecular mechanisms underlying thes...

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Autores principales:	Matthew R. Baker, Ryan Y. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec9ae41d33d043fea5d95072a9e1ad81
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spelling	oai:doaj.org-article:ec9ae41d33d043fea5d95072a9e1ad812021-12-02T17:52:13ZNpas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning10.1038/s41598-021-91495-72045-2322https://doaj.org/article/ec9ae41d33d043fea5d95072a9e1ad812021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91495-7https://doaj.org/toc/2045-2322Abstract Learning to anticipate potentially dangerous contexts is an adaptive behavioral response to coping with stressors. An animal’s stress coping style (e.g. proactive–reactive axis) is known to influence how it encodes salient events. However, the neural and molecular mechanisms underlying these stress coping style differences in learning are unknown. Further, while a number of neuroplasticity-related genes have been associated with alternative stress coping styles, it is unclear if these genes may bias the development of conditioned behavioral responses to stressful stimuli, and if so, which brain regions are involved. Here, we trained adult zebrafish to associate a naturally aversive olfactory cue with a given context. Next, we investigated if expression of two neural plasticity and neurotransmission-related genes (npas4a and gabbr1a) were associated with the contextual fear conditioning differences between proactive and reactive stress coping styles. Reactive zebrafish developed a stronger conditioned fear response and showed significantly higher npas4a expression in the medial and lateral zones of the dorsal telencephalon (Dm, Dl), and the supracommissural nucleus of the ventral telencephalon (Vs). Our findings suggest that the expression of activity-dependent genes like npas4a may be differentially expressed across several interconnected forebrain regions in response to fearful stimuli and promote biases in fear learning among different stress coping styles.Matthew R. BakerRyan Y. WongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew R. Baker Ryan Y. Wong Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
description	Abstract Learning to anticipate potentially dangerous contexts is an adaptive behavioral response to coping with stressors. An animal’s stress coping style (e.g. proactive–reactive axis) is known to influence how it encodes salient events. However, the neural and molecular mechanisms underlying these stress coping style differences in learning are unknown. Further, while a number of neuroplasticity-related genes have been associated with alternative stress coping styles, it is unclear if these genes may bias the development of conditioned behavioral responses to stressful stimuli, and if so, which brain regions are involved. Here, we trained adult zebrafish to associate a naturally aversive olfactory cue with a given context. Next, we investigated if expression of two neural plasticity and neurotransmission-related genes (npas4a and gabbr1a) were associated with the contextual fear conditioning differences between proactive and reactive stress coping styles. Reactive zebrafish developed a stronger conditioned fear response and showed significantly higher npas4a expression in the medial and lateral zones of the dorsal telencephalon (Dm, Dl), and the supracommissural nucleus of the ventral telencephalon (Vs). Our findings suggest that the expression of activity-dependent genes like npas4a may be differentially expressed across several interconnected forebrain regions in response to fearful stimuli and promote biases in fear learning among different stress coping styles.
format	article
author	Matthew R. Baker Ryan Y. Wong
author_facet	Matthew R. Baker Ryan Y. Wong
author_sort	Matthew R. Baker
title	Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
title_short	Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
title_full	Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
title_fullStr	Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
title_full_unstemmed	Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
title_sort	npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec9ae41d33d043fea5d95072a9e1ad81
work_keys_str_mv	AT matthewrbaker npas4aexpressionintheteleostforebrainisassociatedwithstresscopingstyledifferencesinfearlearning AT ryanywong npas4aexpressionintheteleostforebrainisassociatedwithstresscopingstyledifferencesinfearlearning
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Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning

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