Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance

Dong, Vadla et al. find that oncogenic Ras and p53 cooperatively stimulate JAK/STAT cytokines to promote non-autonomous tissue overgrowth in Drosophila. Further, blocking STAT signalling prevents the growth-inducing effect of p53 overexpression and ionising irradiation in human cancer lines in cultu...

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Autores principales:	Yong-Li Dong, Gangadhara P. Vadla, Jin-Yu (Jim) Lu, Vakil Ahmad, Thomas J. Klein, Lu-Fang Liu, Peter M. Glazer, Tian Xu, Chiswili-Yves Chabu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/eca0121cdb5c4fb8ac2dfcc338fcb5ed
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spelling	oai:doaj.org-article:eca0121cdb5c4fb8ac2dfcc338fcb5ed2021-12-02T17:05:09ZCooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance10.1038/s42003-021-01898-52399-3642https://doaj.org/article/eca0121cdb5c4fb8ac2dfcc338fcb5ed2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01898-5https://doaj.org/toc/2399-3642Dong, Vadla et al. find that oncogenic Ras and p53 cooperatively stimulate JAK/STAT cytokines to promote non-autonomous tissue overgrowth in Drosophila. Further, blocking STAT signalling prevents the growth-inducing effect of p53 overexpression and ionising irradiation in human cancer lines in culture and in mouse xenografts, suggesting a therapeutic route.Yong-Li DongGangadhara P. VadlaJin-Yu (Jim) LuVakil AhmadThomas J. KleinLu-Fang LiuPeter M. GlazerTian XuChiswili-Yves ChabuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yong-Li Dong Gangadhara P. Vadla Jin-Yu (Jim) Lu Vakil Ahmad Thomas J. Klein Lu-Fang Liu Peter M. Glazer Tian Xu Chiswili-Yves Chabu Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
description	Dong, Vadla et al. find that oncogenic Ras and p53 cooperatively stimulate JAK/STAT cytokines to promote non-autonomous tissue overgrowth in Drosophila. Further, blocking STAT signalling prevents the growth-inducing effect of p53 overexpression and ionising irradiation in human cancer lines in culture and in mouse xenografts, suggesting a therapeutic route.
format	article
author	Yong-Li Dong Gangadhara P. Vadla Jin-Yu (Jim) Lu Vakil Ahmad Thomas J. Klein Lu-Fang Liu Peter M. Glazer Tian Xu Chiswili-Yves Chabu
author_facet	Yong-Li Dong Gangadhara P. Vadla Jin-Yu (Jim) Lu Vakil Ahmad Thomas J. Klein Lu-Fang Liu Peter M. Glazer Tian Xu Chiswili-Yves Chabu
author_sort	Yong-Li Dong
title	Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
title_short	Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
title_full	Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
title_fullStr	Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
title_full_unstemmed	Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance
title_sort	cooperation between oncogenic ras and wild-type p53 stimulates stat non-cell autonomously to promote tumor radioresistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eca0121cdb5c4fb8ac2dfcc338fcb5ed
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Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance

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