Structural-Dynamics and Binding Analysis of RBD from SARS-CoV-2 Variants of Concern (VOCs) and GRP78 Receptor Revealed Basis for Higher Infectivity

Structural-Dynamics and Binding Analysis of RBD from SARS-CoV-2 Variants of Concern (VOCs) and GRP78 Receptor Revealed Basis for Higher Infectivity

Glucose-regulated protein 78 (GRP78) might be a receptor for SARS-CoV-2 to bind and enter the host cell. Recently reported mutations in the spike glycoprotein unique to the receptor-binding domain (RBD) of different variants might increase the binding and pathogenesis. However, it is still not known...

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Auteurs principaux: Abbas Khan, Anwar Mohammad, Inamul Haq, Mohammad Nasar, Waqar Ahmad, Qudsia Yousafi, Muhammad Suleman, Sajjad Ahmad, Aqel Albutti, Taimoor Khan, Sulaiman K. Marafie, Eman Alshawaf, Syed Shujait Ali, Jehad Abubaker, Dong-Qing Wei
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
COVID-19
SARS-CoV-2
new variants
GRP78
infectivity
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/eca055d1a3644e9792cfcca8455fd873
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https://doaj.org/article/eca055d1a3644e9792cfcca8455fd873

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