Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.

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Autores principales: Akihisa Kato, Shungo Adachi, Shuichi Kawano, Kousuke Takeshima, Mizuki Watanabe, Shinobu Kitazume, Ryota Sato, Hideo Kusano, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii, Tomohisa Hatta, Tohru Natsume, Yasushi Kawaguchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/eca1050db69a44dfa622a351605bfbd6
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spelling oai:doaj.org-article:eca1050db69a44dfa622a351605bfbd62021-12-02T18:51:23ZIdentification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics10.1038/s41467-020-18718-92041-1723https://doaj.org/article/eca1050db69a44dfa622a351605bfbd62020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18718-9https://doaj.org/toc/2041-1723Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.Akihisa KatoShungo AdachiShuichi KawanoKousuke TakeshimaMizuki WatanabeShinobu KitazumeRyota SatoHideo KusanoNaoto KoyanagiYuhei MaruzuruJun AriiTomohisa HattaTohru NatsumeYasushi KawaguchiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Akihisa Kato
Shungo Adachi
Shuichi Kawano
Kousuke Takeshima
Mizuki Watanabe
Shinobu Kitazume
Ryota Sato
Hideo Kusano
Naoto Koyanagi
Yuhei Maruzuru
Jun Arii
Tomohisa Hatta
Tohru Natsume
Yasushi Kawaguchi
Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
description Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.
format article
author Akihisa Kato
Shungo Adachi
Shuichi Kawano
Kousuke Takeshima
Mizuki Watanabe
Shinobu Kitazume
Ryota Sato
Hideo Kusano
Naoto Koyanagi
Yuhei Maruzuru
Jun Arii
Tomohisa Hatta
Tohru Natsume
Yasushi Kawaguchi
author_facet Akihisa Kato
Shungo Adachi
Shuichi Kawano
Kousuke Takeshima
Mizuki Watanabe
Shinobu Kitazume
Ryota Sato
Hideo Kusano
Naoto Koyanagi
Yuhei Maruzuru
Jun Arii
Tomohisa Hatta
Tohru Natsume
Yasushi Kawaguchi
author_sort Akihisa Kato
title Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
title_short Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
title_full Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
title_fullStr Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
title_full_unstemmed Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
title_sort identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/eca1050db69a44dfa622a351605bfbd6
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