The nuclear pore complex prevents sister chromatid recombination during replicative senescence

The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recombination and unleashes a new telomere maintenance m...

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Autores principales:	Paula Aguilera, Jenna Whalen, Christopher Minguet, Dmitri Churikov, Catherine Freudenreich, Marie-Noëlle Simon, Vincent Géli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eca7dfb80a4b4e1f84e98a9a6d5ee4e9
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spelling	oai:doaj.org-article:eca7dfb80a4b4e1f84e98a9a6d5ee4e92021-12-02T16:50:02ZThe nuclear pore complex prevents sister chromatid recombination during replicative senescence10.1038/s41467-019-13979-52041-1723https://doaj.org/article/eca7dfb80a4b4e1f84e98a9a6d5ee4e92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13979-5https://doaj.org/toc/2041-1723The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recombination and unleashes a new telomere maintenance mechanism.Paula AguileraJenna WhalenChristopher MinguetDmitri ChurikovCatherine FreudenreichMarie-Noëlle SimonVincent GéliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paula Aguilera Jenna Whalen Christopher Minguet Dmitri Churikov Catherine Freudenreich Marie-Noëlle Simon Vincent Géli The nuclear pore complex prevents sister chromatid recombination during replicative senescence
description	The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recombination and unleashes a new telomere maintenance mechanism.
format	article
author	Paula Aguilera Jenna Whalen Christopher Minguet Dmitri Churikov Catherine Freudenreich Marie-Noëlle Simon Vincent Géli
author_facet	Paula Aguilera Jenna Whalen Christopher Minguet Dmitri Churikov Catherine Freudenreich Marie-Noëlle Simon Vincent Géli
author_sort	Paula Aguilera
title	The nuclear pore complex prevents sister chromatid recombination during replicative senescence
title_short	The nuclear pore complex prevents sister chromatid recombination during replicative senescence
title_full	The nuclear pore complex prevents sister chromatid recombination during replicative senescence
title_fullStr	The nuclear pore complex prevents sister chromatid recombination during replicative senescence
title_full_unstemmed	The nuclear pore complex prevents sister chromatid recombination during replicative senescence
title_sort	nuclear pore complex prevents sister chromatid recombination during replicative senescence
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/eca7dfb80a4b4e1f84e98a9a6d5ee4e9
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The nuclear pore complex prevents sister chromatid recombination during replicative senescence

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