The nuclear pore complex prevents sister chromatid recombination during replicative senescence

The nuclear pore complex prevents sister chromatid recombination during replicative senescence

The Nuclear Pore Complex has been linked to DNA damage processing. Here the authors reveal that the Nup1 C-terminus is critical for the relocalization of eroded telomeres to nuclear pores and that modification of Nup1 promotes sister chromatid recombination and unleashes a new telomere maintenance m...

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Main Authors: Paula Aguilera, Jenna Whalen, Christopher Minguet, Dmitri Churikov, Catherine Freudenreich, Marie-Noëlle Simon, Vincent Géli
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/eca7dfb80a4b4e1f84e98a9a6d5ee4e9
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