A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.

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Detalles Bibliográficos
Autores principales: Alisa A. Garaeva, Albert Guskov, Dirk J. Slotboom, Cristina Paulino
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ecaafebc4c2640a4ad0f1aaa6f025884
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Sumario:How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.