A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.

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Autores principales:	Alisa A. Garaeva, Albert Guskov, Dirk J. Slotboom, Cristina Paulino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ecaafebc4c2640a4ad0f1aaa6f025884
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spelling	oai:doaj.org-article:ecaafebc4c2640a4ad0f1aaa6f0258842021-12-02T15:35:17ZA one-gate elevator mechanism for the human neutral amino acid transporter ASCT210.1038/s41467-019-11363-x2041-1723https://doaj.org/article/ecaafebc4c2640a4ad0f1aaa6f0258842019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11363-xhttps://doaj.org/toc/2041-1723How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.Alisa A. GaraevaAlbert GuskovDirk J. SlotboomCristina PaulinoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alisa A. Garaeva Albert Guskov Dirk J. Slotboom Cristina Paulino A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
description	How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.
format	article
author	Alisa A. Garaeva Albert Guskov Dirk J. Slotboom Cristina Paulino
author_facet	Alisa A. Garaeva Albert Guskov Dirk J. Slotboom Cristina Paulino
author_sort	Alisa A. Garaeva
title	A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
title_short	A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
title_full	A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
title_fullStr	A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
title_full_unstemmed	A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
title_sort	one-gate elevator mechanism for the human neutral amino acid transporter asct2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ecaafebc4c2640a4ad0f1aaa6f025884
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A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

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